Author
Kailash C. Malhotra
Other affiliations: University of Hamburg, Savitribai Phule Pune University, University of Texas Health Science Center at Houston ...read more
Bio: Kailash C. Malhotra is an academic researcher from Indian Statistical Institute. The author has contributed to research in topics: Population & Dermatoglyphics. The author has an hindex of 20, co-authored 75 publications receiving 1058 citations. Previous affiliations of Kailash C. Malhotra include University of Hamburg & Savitribai Phule Pune University.
Papers published on a yearly basis
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TL;DR: The observed clusterings among these nine endogamous groups of Maharashtra, in general, are compatible with the known ethnic history of Maharashtra.
20 citations
TL;DR: Six Mongoloid and four Caucasoid populations of Assam, India, were examined for A1A2BO, Rhesus, Duffy and Diego blood groups and the distribution of their phenotypes and allele frequencies.
Abstract: Six Mongoloid and four Caucasoid populations of Assam, India, were examined for A1A2BO, Rhesus, Duffy and Diego blood groups. The distribution of their phenotypes and allele frequencies are presented. In the perspective of the ethnographic background, the results have been discussed in terms of genetic variability among these populations and probable reasons for its existence. The major groups, namely Caucasoids and Mongoloids, appear to form two separate groups in terms of these blood groups, though evidence is there to suggest intermixture.
20 citations
TL;DR: Variation in quantitative dermatoglyphics among three endogamous groups of marine fishermen of Puri Coast, India, is greater for the palmar variables than for the fingers.
Abstract: Variation in quantitative dermatoglyphics among three endogamous groups of marine fishermen of Puri Coast, India, is greater for the palmar variables than for the fingers. This is the case in both the sexes. The pattern of population affinities, however, differs for the males and females. In order to evaluate the importance of palmar variables in population studies, the results in males are compared with those of finger variables and anthropometrics. There is no significant heterogeneity between the groups for finger variables. Although significant intergroup variability is observed in the palmar and anthropometric traits, the two sets of results are not in the same direction. Palmar dermatoglyphic relationships reflect the caste affiliations, while the anthropometric are in line with geographic proximity.
17 citations
01 Jan 1984
TL;DR: Malhotra et al. as discussed by the authors found that about 7% of India's population are nomads, and that some are completely sedentary; others are seminomads; and still others are true nomads who move during the year in a cyclical rhythmic manner in a more or less fixed territory.
Abstract: Indian society consists of more than 4000 endogamous castes, tribes, and religious communities (Malhotra, 1979a). Of these, some 500 groups, constituting about 7% of India’s population are nomads (Malhotra, 1983). These nomads are in various stages of nomadism; some are completely sedentary; others are seminomads, and still others are true nomads. True nomads are the ones who move during the year in a cyclical rhythmic manner in a more or less fixed territory and who have no permanent dwellings and practice no agriculture (Bacon, 1954). The seminomads have permanent dwellings and may engage in agriculture or other persuits, but they migrate only during part of the year.
17 citations
TL;DR: Serological and anthropometric data reveal a considerable genetic variability of the groups under study, which is obviously connected with the population history of West Bengal.
Abstract: Ten endogamous population groups of West Bengal (India)--Rabhas, Garos, Mechs, Rajbanshis, Jalia Kaibartas, Bagdis, Lodhas, Mundas, Brahmins, Vaidyas--have been typed for twelve polymorphic systems: ABO, Gm, Km, Hp, Cp, Tf, Alb, Hb, aP, EsD, AK and PGM1. The results are compared with those obtained on other Indian populations. Serological and anthropometric data, which have been included into population comparisons, reveal a considerable genetic variability of the groups under study. This variability is obviously connected with the population history of West Bengal.
15 citations
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1,532 citations
TL;DR: These estimates can help countries and the international community gauge the need for appropriate diagnoses and genetic counselling to reduce the number of neonates affected by HbS and could be used for other inherited disorders.
838 citations
TL;DR: The magnitude and variation in global, regional, and country-level prevalence rates of G6PD deficiency are of public health import, particularly in planning programs to improve neonatal health and in the distribution of various medications, especially antimalarial drugs, as G6 PD deficiency is most prevalent in malaria-endemic areas.
Abstract: Glucose-6-phosphate deficiency is the most prevalent enzyme deficiency, with an estimated 400 million people affected worldwide. This inherited deficiency causes neonatal hyperbilirubinemia and chronic hemolytic anemia. Although most affected individuals are asymptomatic, exposure to oxidative stressors such as certain drugs or infection, can elicit acute hemolysis. To characterize the global prevalence of G6PD deficiency, we conducted a systematic review of the G6PD deficiency literature, drawing studies from various databases, including MEDLINE/Pubmed and Biosis. Selected studies included cross-sectional and longitudinal studies published between 1960 and 2008. Additionally, meta-analytic procedures were employed to assess the degree of heterogeneity amongst prevalence estimates and, where appropriate, pool them. The searches yielded a total of 280 prevalence estimates, corresponding to 88 countries. The highest prevalence rates were reported among Sub-Saharan African countries, even after adjusting for assessment method. Meta-analysis revealed a high degree of heterogeneity for regional and global prevalence estimates. This heterogeneity in reported estimates appeared to be due to differences in G6PD deficiency assessment and diagnostic procedures. The magnitude and variation in global, regional, and country-level prevalence rates of G6PD deficiency are of public health import, particularly in planning programs to improve neonatal health and in the distribution of various medications, especially antimalarial drugs, as G6PD deficiency is most prevalent in malaria-endemic areas.
557 citations
489 citations
TL;DR: This work uses a comprehensive data assembly of HbS allele frequencies to generate the first evidence-based map of the worldwide distribution of the gene in a Bayesian geostatistical framework and finds geographical support for the malaria hypothesis globally.
Abstract: It has been 100 years since the first report of sickle haemoglobin (HbS). More than 50 years ago, it was suggested that the gene responsible for this disorder could reach high frequencies because of resistance conferred against malaria by the heterozygous carrier state. This traditional example of balancing selection is known as the 'malaria hypothesis'. However, the geographical relationship between the transmission intensity of malaria and associated HbS burden has never been formally investigated on a global scale. Here, we use a comprehensive data assembly of HbS allele frequencies to generate the first evidence-based map of the worldwide distribution of the gene in a Bayesian geostatistical framework. We compare this map with the pre-intervention distribution of malaria endemicity, using a novel geostatistical area-mean comparison. We find geographical support for the malaria hypothesis globally; the relationship is relatively strong in Africa but cannot be resolved in the Americas or in Asia.
472 citations