K
Kaitlyn N. Lewis
Researcher at University of Texas Health Science Center at San Antonio
Publications - 26
Citations - 7195
Kaitlyn N. Lewis is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Naked mole-rat & Longevity. The author has an hindex of 17, co-authored 25 publications receiving 6603 citations. Previous affiliations of Kaitlyn N. Lewis include University of Texas at Austin & National Institutes of Health.
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Journal ArticleDOI
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur,Kevin J. Pearson,Nathaniel O Price,Hamish A. Jamieson,Carles Lerin,Avash Kalra,Vinayakumar Prabhu,Joanne S. Allard,Guillermo López-Lluch,Kaitlyn N. Lewis,Paul J. Pistell,Suresh Poosala,Kevin G. Becker,Olivier Boss,Dana M. Gwinn,Mingyi Wang,Sharan Ramaswamy,Kenneth W. Fishbein,Richard G. Spencer,Edward G. Lakatta,David G. Le Couteur,Reuben J. Shaw,Plácido Navas,Pere Puigserver,Donald K. Ingram,Rafael de Cabo,David A. Sinclair +26 more
TL;DR: It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.
Journal ArticleDOI
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
Kevin J. Pearson,Joseph A. Baur,Kaitlyn N. Lewis,Leonid Peshkin,Nathan L. Price,Nathan L. Price,Nazar Labinskyy,William R. Swindell,Davida Kamara,Robin K. Minor,Evelyn Perez,Hamish A. Jamieson,Yongqing Zhang,Stephen R. Dunn,Kumar Sharma,Nancy Pleshko,Laura A. Woollett,Anna Csiszar,Yuji Ikeno,David G. Le Couteur,Peter J. Elliott,Kevin G. Becker,Plácido Navas,Donald K. Ingram,Norman S. Wolf,Zoltan Ungvari,David A. Sinclair,Rafael de Cabo +27 more
TL;DR: It is found that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife.
Journal ArticleDOI
SIRT1 is essential for normal cognitive function and synaptic plasticity
Shaday Michan,Ying Li,Maggie Meng Hsiu Chou,Edoardo Parrella,Huanying Ge,Jeffrey M. Long,Joanne S. Allard,Kaitlyn N. Lewis,Marshall G. Miller,Wei Xu,Ronald F. Mervis,Jing Chen,Karen I. Guerin,Lois E.H. Smith,Michael W. McBurney,David A. Sinclair,Michel Baudry,Rafael de Cabo,Valter D. Longo +18 more
TL;DR: It is shown that SIRT1 is expressed in neurons of the hippocampus, a key structure in learning and memory and indispensable for normal learning, memory, and synaptic plasticity in mice.
Journal ArticleDOI
Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet
Yolanda Jimenez-Gomez,Julie A. Mattison,Kevin J. Pearson,Kevin J. Pearson,Alejandro Martin-Montalvo,Hector H. Palacios,Alex M. Sossong,Theresa M. Ward,Caitlin M. Younts,Kaitlyn N. Lewis,Joanne S. Allard,Joanne S. Allard,Dan L. Longo,Jonathan P. Belman,María M. Malagón,Plácido Navas,Mitesh Sanghvi,Ruin Moaddel,Edward M. Tilmont,Richard Herbert,Christopher H. Morrell,Josephine M. Egan,Joseph A. Baur,Luigi Ferrucci,Jonathan S. Bogan,Michel Bernier,Rafael de Cabo +26 more
TL;DR: Chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys, which is associated with a chronic, low-grade, systemic inflammation.
Journal ArticleDOI
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
Kevin J. Pearson,Kaitlyn N. Lewis,Nathan L. Price,Joy W. Chang,Evelyn Perez,María V. Cascajo,Kellie L.K. Tamashiro,Suresh Poosala,Anna Csiszar,Zoltan Ungvari,Thomas W. Kensler,Masayuki Yamamoto,Josephine M. Egan,Dan L. Longo,Donald K. Ingram,Donald K. Ingram,Plácido Navas,Rafael de Cabo,Rafael de Cabo +18 more
TL;DR: It is shown that Nrf2 is responsible for most of the anticarcinogenic effects of CR, but is dispensable for increased insulin sensitivity and lifespan extension, and a molecular pathway is identified that dissociates the prolongevity and anticarc in CR.