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Kaixian Chen
Researcher at Chinese Academy of Sciences
Publications - 403
Citations - 11476
Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.
Papers
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Journal ArticleDOI
QSAR analyses on ginkgolides and their analogues using CoMFA, CoMSIA, and HQSAR.
Weiliang Zhu,Gang Chen,Lihong Hu,Xiaomin Luo,Chunshan Gui,Chunshan Gui,Cheng Luo,Chum Mok Puah,Kaixian Chen,Hualiang Jiang +9 more
TL;DR: The possible binding mechanism between ginkgolides and human PAF receptor was deduced based on the QSAR models and should be very helpful in discovering new drugs as PAF antagonists in fighting against various diseases related to PAF andPAF receptor.
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Brownian Dynamics Simulations of Interaction Between Scorpion Toxin Lq2 and Potassium Ion Channel
Meng Cui,Jianhua Shen,James M. Briggs,Xiaomin Luo,Xiaojian Tan,Hualiang Jiang,Kaixian Chen,Ruyun Ji +7 more
TL;DR: The consistency between the BD simulation and the experimental data indicates that the three-dimensional model of Lq2-K(+) channel complex is reasonable and can be used in further biological studies such as rational design of blocking agents of K(+ channels and mutagenesis in both toxins and K(+) channels.
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Estimation of acute oral toxicity in rat using local lazy learning.
Jing Lu,Jing Lu,Jianlong Peng,Jinan Wang,Qiancheng Shen,Yi Bi,Likun Gong,Mingyue Zheng,Xiaomin Luo,Weiliang Zhu,Hualiang Jiang,Hualiang Jiang,Hualiang Jiang,Kaixian Chen,Kaixian Chen +14 more
TL;DR: A consensus model based on the predicted values of individual LLL models of LD50 is developed, yielding correlation coefficients R2 of 0.712 on a test set containing 2,896 compounds.
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Syntheses, crystal structures and properties of Zn(II) and Cd(II) complexes derived from N-(o-nitrophenyl)-N′-(methoxycarbonyl) thiourea(H2omt) and 2,2′-bipyridine(bpy) or o-phenanthroline(phen)
TL;DR: In this paper, the chelating properties of N-(o-nitrophenyl)-N′-(methoxycarbonyl)thiourea (H2omt) were investigated through the study of the crystal structures of Cd(Homt)2(bpy), 1, 1, Zn(Homte-phen), 2 and 2 and H 2omt (bpy=2,2′-bipyridine, phen=o-phenanthroline).
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Advance in biological activities of natural guaiane-type sesquiterpenes
TL;DR: Guan et al. as mentioned in this paper summarized the distribution of guaiane-type sesquiterpenes in plants, the possible biogenic pathways and chemical structures as well as the research progress on their biological activities from 1990 to 2018.