K
Kaixian Chen
Researcher at Chinese Academy of Sciences
Publications - 403
Citations - 11476
Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.
Papers
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Journal ArticleDOI
Design, synthesis, antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives
Haihong Li,Xiu-Hua Zhang,Jinzhi Tan,Lili Chen,Hong Liu,Xiaomin Luo,Xu Shen,Xu Shen,Liping Lin,Kaixian Chen,Jian Ding,Hualiang Jiang,Hualiang Jiang +12 more
TL;DR: This study provides a new template for further development of potent antitumor drugs by synthesizing a series of novel 3,5-substituted indolin-2-one compounds, featuring the 3,--+ 2-one core and β-pyrrole group, based on enzyme binding features of (Z)-SU5402.
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An Overall Picture of SARS Coronavirus (SARS-CoV) Genome-Encoded Major Proteins: Structures, Functions and Drug Development
Shuai Chen,Haibin Luo,Lili Chen,Jing Chen,Jianhua Shen,Weiliang Zhu,Kaixian Chen,Xu Shen,Hualiang Jiang +8 more
TL;DR: The concerted and cooperative response for the treatment of the SARS disease has been proved to be a triumph of global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats.
Journal ArticleDOI
Mapping central α-helix linker mediated conformational transition pathway of calmodulin via simple computational approach.
Jinan Wang,Shaoliang Peng,Benjamin P. Cossins,Xiangke Liao,Kaixian Chen,Qiang Shao,Xiaoqian Zhu,Jiye Shi,Weiliang Zhu +8 more
TL;DR: Novel insights are provided into the correlation of the integrity of protein, the structural flexibility, and the mechanism of conformational transition of proteinlike calmodulin.
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Transformation of Aryl Acyloin O‐Alkyl and O‐Phenyl Derivatives to Ketones
TL;DR: In this article, the treatment of aryl acyloin (α-hydroxyketone) O−alkyl and O−phenyl derivatives with 2-3 equiv of Zn and 1 2 -equiv of NH4Cl in ethanol, refluxing for 20-120 min, gave the corresponding ketones with excellent yields.
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Synthesis and antibacterial activity of oxazolidinone containing sulphonyl group.
TL;DR: A series of oxazolidinone derivatives carrying sulphonyl group was synthesized and their antibacterial activity was evaluated in vitro.