K
Kaixian Chen
Researcher at Chinese Academy of Sciences
Publications - 403
Citations - 11476
Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.
Papers
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Journal ArticleDOI
Identification of novel small-molecule inhibitors targeting menin–MLL interaction, repurposing the antidiarrheal loperamide
Liyan Yue,Juanjuan Du,Fei Ye,Zhifeng Chen,Lianchun Li,Fulin Lian,Bidong Zhang,Yuanyuan Zhang,Hualiang Jiang,Kaixian Chen,Kaixian Chen,Yuanchao Li,Bing Zhou,Naixia Zhang,Yaxi Yang,Cheng Luo,Cheng Luo +16 more
TL;DR: Molecules of a novel scaffold targeting menin-MLL interactions were reported and they may serve as new potential therapeutic agents for MLL leukemia.
Journal ArticleDOI
Revisit of a dipropargyl rhodamine probe reveals its alternative ion sensitivity in both a solution and live cells
Kai-Bin Li,Xiao-Li Wei,Xiao-Li Wei,Yi Zang,Xiao-Peng He,Guo-Rong Chen,Jia Li,Kaixian Chen,Kaixian Chen +8 more
TL;DR: A dipropargyl rhodamine B derivative previously described as a reaction-based irreversible palladium probe responds, however, more sensitively to mercury with a reversible "turn-on" fluorescence.
Journal ArticleDOI
Discovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assay.
Zhifeng Chen,Zhifeng Chen,Hao Zhang,Shien Liu,Yiqian Xie,Hao Jiang,Wenchao Lu,Heng Xu,Liyan Yue,Yuanyuan Zhang,Hong Ding,Hong Ding,Mingyue Zheng,Kunqian Yu,Kaixian Chen,Hualiang Jiang,Hualiang Jiang,Cheng Luo +17 more
TL;DR: These compounds exhibited anti-proliferation activity, caused cell cycle arrest, and induced apoptosis in human leukemia MV4-11 cells, indicating the potential of this series of compounds as drug candidates for the therapy of BRD4-related cancers.
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Discovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay
Zhongjie Liang,Xiao Ding,Jing Ai,Xiangqian Kong,Limin Chen,Liang Chen,Cheng Luo,Cheng Luo,Meiyu Geng,Hong Liu,Kaixian Chen,Hualiang Jiang +11 more
TL;DR: These findings identified the pyrazolidine-3,5-dione derivatives as potent inhibitors against c-Met kinase and demonstrated the efficiency of the strategy in the development of small molecules against the receptor tyrosine kinase.
Journal ArticleDOI
Estimation of carcinogenicity using molecular fragments tree.
Yong Wang,Jing Lu,Fei Wang,Qiancheng Shen,Mingyue Zheng,Xiaomin Luo,Weiliang Zhu,Hualiang Jiang,Kaixian Chen +8 more
TL;DR: A method to extract structural alerts (SAs) and modulating factors of carcinogens on the basis of statistical analyses and an automated and unbiased manner that does not rely on a priori knowledge of mechanism of action is developed.