K
Kaixian Chen
Researcher at Chinese Academy of Sciences
Publications - 403
Citations - 11476
Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.
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Patent
Fluorinated cyclopropylamine compound, preparation method therefor, pharmaceutical composition thereof, and uses thereof
Liu Hong,Li Jia,Jiang Wang,Su Mingbo,Shuni Wang,Zhou Yubo,Zhu Wei,Xu Wei,Chunpu Li,Hualiang Jiang,Kaixian Chen +10 more
TL;DR: In this article, a fluorinated cyclopropylamine compound represented by formula I, a racemate thereof, an R-isomer thereof, a Sisomer of the compound, a pharmaceutical salt thereof, and a mixture thereof is described.
Journal ArticleDOI
The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations
TL;DR: The inhibitory mechanism of ATA targeting Stp1 is indicated using molecular dynamics simulations and sheds light on the future design of allosteric St p1 inhibitors.
Journal ArticleDOI
Discovery of novel USP8 inhibitors via Ubiquitin-Rho-110 fluorometric assay based high throughput screening.
Jie Han,Yucheng Tian,Liang Yu,Qilin Zhang,Xi Xu,Yichao Zhang,Jubo Wang,Zengyi Ma,Jinlei Bian,Cheng Luo,Hualiang Jiang,Kaixian Chen,Yao Zhao,Zhiyu Li,Hong Ding,Hong Ding +15 more
TL;DR: USP8 inhibitors with novel scaffold with broad prospects for being a probe for USP8-related academic and clinical research are discovered via high throughput screening based on Ubiquitin-rhodamine-110 (Ubiquit in-Rho-110) fluorometric activity assay.
Journal ArticleDOI
An Efficient One-Pot Synthesis of Substituted 2-Aminothiophenes via Three-Component Gewald Reaction Catalyzed by L-Proline.
Tao Wang,Xian-Gui Huang,Jia Liu,Bo Li,Jin-Jin Wu,Kaixian Chen,Weiliang Zhu,Xiao-Yong Xu,Bu-Bing Zeng +8 more
Journal ArticleDOI
Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors
Xiaoyang Bi,Yu Chen,Zhongya Sun,Wenchao Lu,Pan Xu,Tian Lu,Hong Ding,Naixia Zhang,Hualiang Jiang,Kaixian Chen,Bing Zhou,Cheng Luo +11 more
TL;DR: DC-CPin734 showing good potency, selectivity and anti AML activity could serve as a potent and selective in vitro and in vivo probe of CBP bromodomain and a promising lead compound for future drug development.