K
Kaixian Chen
Researcher at Chinese Academy of Sciences
Publications - 403
Citations - 11476
Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.
Papers
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Journal ArticleDOI
A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6
Liping Liao,Wen-Zhen Dang,Tingting Lin,Jing-hong Yu,Tonghai Liu,Wen H Li,Senhao Xiao,Lei Feng,Jing Huang,Rong Fu,Jia-cheng Li,Liping Liu,Mingchen Wang,Hongrui Tao,Hualiang Jiang,Kaixian Chen,Xingxing Diao,Bing-Bing Zhou,Xi Shen,Cheng Luo +19 more
TL;DR: DC-PGKI as mentioned in this paper is an ATP-competitive inhibitor of PGK1 with an affinity of Kd = 99.08 nmol/L. DC-PGK1 stabilizes PGK 1 in vitro and in vivo, and suppresses both glycolytic activity and the kinase function.
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L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression
Jing Huang,Xiaobo Wang,Shiyu Shen,Ruina Wang,Hongrui Tao,Junchi Hu,Jin Yu,Hualiang Jiang,Kaixian Chen,Cheng Luo,Yongjun Dang,Yuanyuan Zhang +11 more
TL;DR: This study illustrated L-5-HTP’s inhibitory effect on PD-L1 induction stimulated by IFN-γ in tumor cells and also provided insight into repurposing L- 5- HTP for use in tumor immunotherapy.
Journal Article
Molecular modeling of interactions between tetrahydroprotoberberines and dopamine receptors.
TL;DR: The authors' ligand-receptor interaction models should be helpful for rational design of more potent drugs, and the possible action mechanism of THPB on dopamine receptors was suggested.
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Metal-free quinolylation of the primary amino groups of amino acid derivatives and peptides with dihydrooxazolo[3,2-a]quinoliniums
Peng Liu,Bo Li,Mengyu Xi,Zhaoqiang Chen,Haiguo Sun,Xiajuan Huan,Xuejun Xu,Yong Zhang,Kun Zou,Xiangrui Jiang,Miao Zehong,Jinggen Liu,Jingshan Shen,Kaixian Chen,Weiliang Zhu +14 more
TL;DR: In this article, a method to selectively modify primary amino groups using dihydrooxazolo[3,2-a]quinoliniums in 1-butanol as solvent under mild and metal-free conditions is presented.
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One-Pot Approach for C-CBond Formation through Ruthenium-Amido Complex Catalyzed TandemAldol Reaction/Hydrogenation
TL;DR: In this article, a one-pot approach was developed for α-alkylation of various nitriles with carbonyl compounds using ruthenium-amido complex catalyst.