K
Kaixian Chen
Researcher at Chinese Academy of Sciences
Publications - 403
Citations - 11476
Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.
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Patent
5-lipoxygenase inhibitor and preparation method, medical composite and application thereof
TL;DR: In this article, a 5-lipoxygenase inhibitor and a preparation method, a medical composite and an application thereof are presented. And the biological activity experiment shows that the compound of the invention is effective 5-LOX small molecule inhibitor with novel structure.
Journal ArticleDOI
Theoretical studies on cation-π interactions (I)——Density-functional theory investigation on the configurations and interaction for ammonium cation-benzene complex
Hualiang Jiang,Weiliang Zhu,Xiao-Jian Tan,Jiande Gu,Jianzhong Chen,Maowei Lin,Kaixian Chen,Ruyun Ji +7 more
TL;DR: In this paper, the density functional theory (DFT) approach of B3LYP/6-31G* has been employed to calculate the six possible configurations of ammonium cation-benzene complex (NH4+ -C6H6).
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Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists.
Bin Shan,Hui Hou,Keke Zhang,Rui-Jun Li,Chan-Juan Shen,Zhengyang Chen,Peijia Xu,Rong-Hua Cui,Zhaoming Su,Changfa Zhang,Ruirui Yang,Guizhen Zhou,Yadan Liu,Hao Guo,Kaixian Chen,Wei Fu,Hualiang Jiang,Sulin Zhang,Mingyue Zheng +18 more
TL;DR: Based on the crystal structure of SR-717 bound to hSTING, a series of bipyridazine derivatives were designed and synthesized as highly potent STING agonists as discussed by the authors .
Journal ArticleDOI
Activation of Peroxiredoxin 1 by Fluvastatin Effectively Protects from Inflammation and SARS-CoV-2
Hao Zhang,Jing Shen,Heng Xu,Jing Sun,Wen Yin,Yu Zuo,Zhangzhao Wang,Fengmin Xiong,Yuqi Zhang,Hua Lin,Jingqiu Liu,Yiluan Ding,Naixia Zhang,Hualiang Jiang,Kaixian Chen,Weiping Zhang,Kehao Zhao,Kehao Zhao,Jincun Zhao,Xiangyang Xie,Cheng Luo +20 more
TL;DR: Excessive reactive oxygen species is highly involved in inflammation and the pathogenesis of infectious diseases as a potent scavenger of ROS, peroxiredo.
Journal Article
Antimycoplasmal activities of (S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10 -[4-(2-pyridyl)-1-piperazinyl]-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine -6-carboxylic acid (YH-6) in comparison with other antibiotics in vitro.
TL;DR: YH-6 was a highly active quinolone against Mycoplasma, but could hardly induce resistance to Uu.