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Kaixian Chen
Researcher at Chinese Academy of Sciences
Publications - 403
Citations - 11476
Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.
Papers
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Journal ArticleDOI
Discovery of N-Substituted 3-Arylisoquinolone Derivatives as Antitumor Agents Originating from O-Substituted 3-Arylisoquinolines via [2,3] or [3,3] Rearrangement.
Bo Li,Gaihong Wang,Zhijian Xu,Yong Zhang,Xian-Gui Huang,Bubing Zeng,Kaixian Chen,Jiye Shi,He-Yao Wang,Weiliang Zhu +9 more
TL;DR: A variety of N-substituted 3-aryl isoquinolone derivatives are synthesized via [2,3] or [3,3]- rearrangement reactions as mentioned in this paper.
Patent
1-(3-aminopropyl) substituted cyclic amine compounds, preparation method therefor, and pharmaceutical compositions and uses thereof
Hong Liu,Beili Wu,Yong-Tang Zheng,Xin Xie,Hualiang Jiang,Peng Panfeng,Rong-Hua Luo,Jing Li,Jian Li,Zhu Yingchun,Chen Ying,Haonan Zhang,Liu-Meng Yang,Yu Zhou,Kaixian Chen +14 more
TL;DR: In this article, a method of synthesizing 1-(3-aminopropyl) substituted cyclic amine compounds by using aromatic heterocyclic formaldehyde as raw material is presented.
Journal ArticleDOI
Synthesis and Antibacterial Activity of Oxazolidinone Containing Sulfonyl Group.
Patent
3D-structure model of SARS coronavirus 3CL protease and anti-SARS drugs
Jianhua Shen,Hualiang Jiang,Xu Shen,Jianping Zuo,Xiaomin Luo,Donglu Bai,Jingkang Shen,Kaixian Chen,Chunshan Gui,Lili Chen,Jing Chen,Yifu Yang,Xianhan Zhuang,Yiming Yang,Xuchang He,Hong Liu,Bing Xiong,Haibin Luo,Tao Sun,Fei Ye +19 more
TL;DR: Cinanserin analogs were synthesized and tested at molecular and viral levels, they were found to be able to inhibit the SARS-CoV virus 3CL Protease as mentioned in this paper.