K
Kaixian Chen
Researcher at Chinese Academy of Sciences
Publications - 403
Citations - 11476
Kaixian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Chemistry. The author has an hindex of 47, co-authored 380 publications receiving 9209 citations. Previous affiliations of Kaixian Chen include Shanghai University & East China University of Science and Technology.
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Journal ArticleDOI
Ligand-free iron/copper cocatalyzed N-arylations of aryl halides with amines under microwave irradiation
Diliang Guo,Diliang Guo,He Huang,Yu Zhou,Jinyi Xu,Hualiang Jiang,Kaixian Chen,Kaixian Chen,Hong Liu,Hong Liu +9 more
TL;DR: Ligand-free iron/copper cocatalyzed cross-coupling reactions of aryl halides with amines were carried out to provide the corresponding coupling products in good yields.
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Identification of diverse 1,2,3-triazole-connected benzyl glycoside-serine/threonine conjugates as potent corrosion inhibitors for mild steel in HCl
Qiong Deng,Na-Na Ding,Xiao-Li Wei,Liang Cai,Xiao-Peng He,Yi-Tao Long,Guo-Rong Chen,Kaixian Chen,Kaixian Chen +8 more
TL;DR: It is suggested that benzyl glycoside-amino acid hybrids effectively constructed via the Cue-AAC between the highly biocompatible sugars and amino acids may represent a new class of promising and potentially green corrosion inhibitors.
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Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2 and serotonin 5-HT1A multi-action profile
Haifeng Sun,Liyuan Zhu,Huicui Yang,Wangke Qian,Lin Guo,Shengbin Zhou,Bo Gao,Zeng Li,Yu Zhou,Hualiang Jiang,Kaixian Chen,Xuechu Zhen,Xuechu Zhen,Hong Liu +13 more
TL;DR: The results suggest that these two THPBs compounds targeted to multiple neurotransmitter receptors may present novel lead drugs with new pharmacological profiles for the treatment of schizophrenia.
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Diverse Mechanisms of Antidiabetic Effects of the Different Procyanidin Oligomer Types of Two Different Cinnamon Species on db/db Mice
Liang Chen,Peng Sun,Peng Sun,Ting Wang,Kaixian Chen,Kaixian Chen,Qi Jia,He-Yao Wang,Yiming Li +8 more
TL;DR: Investigation of the hypoglycemic effects of different procyanidin oligomer types in cinnamon extracts found that CC-E promoted lipid accumulation in the adipose tissue and liver, whereas CT-E mainly improved the insulin concentration in the blood and pancreas.
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Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-Neuroinflammatory Agents for Ischemic Stroke.
Cheng‐Long Gao,Gui‐Ge Hou,Gui‐Ge Hou,Jin Liu,Tong Ru,Yazhou Xu,Shunyi Zhao,Hui Ye,Luyong Zhang,Kaixian Chen,Yue-Wei Guo,Tao Pang,Xu-Wen Li +12 more
TL;DR: 10i exhibited anti-neuroinflammatory effect in vitro and in vivo via inhibiting PKM2-mediated glycolysis and NLRP3 activation, indicating PKM 2 as a novel target for neuroinflammation and its related brain disorders.