Kalipada Manna

Bio: Kalipada Manna is an academic researcher from University of Calcutta. The author has contributed to research in topics: Self-healing hydrogels & Chemistry. The author has an hindex of 1, co-authored 1 publications receiving 18 citations.

β-Cyclodextrin-Based Ultrahigh Stretchable, Flexible, Electro- and Pressure-Responsive, Adhesive, Transparent Hydrogel as Motion Sensor.

Abstract: In the present work, a multiple-stimuli-responsive hydrogel has been synthesized via polymerization of acrylamide (AAm) and N-hydroxy methyl acrylamide (HMAm) on β-cyclodextrin (β-CD). The synthesized hydrogel β-CD-g-(pAAm/pHMAm) exhibited various striking features like ultrahigh stretchability (>6000%), flexibility, stab resistivity, self-recoverability, electroresponsiveness, pressure-responsiveness, adhesiveness, and high transparency (>90%). Besides, the hydrogel has demonstrated enhanced biocompatibility, UV resistance, and thermoresponsive shape memory behaviors. On the basis of these attractive characteristics of the hydrogel, a flexible pressure sensor for the real-time monitoring of human motion with superior biocompatibility and transparency was fabricated. Moreover, due to the nanofibrillar surface morphology of the β-CD-g-(pAAm/pHMAm) hydrogel, the sensor based on the gel exhibited high sensitivity (0.053 kPa-1 for 0-3.3 kPa). The flexible sensor demonstrates very fast response time (130 ms-210 ms) with adequate stability (5000 cycles). Interestingly, the sensor can rapidly sense both robust (index finger and wrist) motions as well as tiny (swallowing and phonation) physiological actions. In addition, this adhesive hydrogel patch also acts as a potential carrier for the sustained topical release of (∼80.8% in 48 h) the antibiotic drug gentamicin sulfate.

Recent Advances in Various Stimuli-Responsive Hydrogels: From Synthetic Designs to Emerging Healthcare Applications

Abstract: With the development of the broad interest in the synthesis of unique stimuli-responsive materials and their various healthcare applications, the stimuli-responsive hydrogels have drawn major importance. Moreover, the hydrogels have...

The Role of Amino Acids in Neurotransmission and Fluorescent Tools for Their Detection

Abstract: Neurotransmission between neurons, which can occur over the span of a few milliseconds, relies on the controlled release of small molecule neurotransmitters, many of which are amino acids. Fluorescence imaging provides the necessary speed to follow these events and has emerged as a powerful technique for investigating neurotransmission. In this review, we highlight some of the roles of the 20 canonical amino acids, GABA and β-alanine in neurotransmission. We also discuss available fluorescence-based probes for amino acids that have been shown to be compatible for live cell imaging, namely those based on synthetic dyes, nanostructures (quantum dots and nanotubes), and genetically encoded components. We aim to provide tool developers with information that may guide future engineering efforts and tool users with information regarding existing indicators to facilitate studies of amino acid dynamics.

A Chemodosimetric Approach for Fluorimetric Detection of Hg2+ Ions by Trinuclear Zn(II)/Cd(II) Schiff Base Complex: First Case of Intermediate Trapping in a Chemodosimetric Approach.

Abstract: The present work discloses the application of two fluorescent zinc and cadmium complexes (1 and 2) for sensing of Hg(II) ions through a chemodosimetric approach. The ligand under consideration in this work is a N2O donor Schiff base ligand (E)-4-bromo-2-(((2-morpholinoethyl)imino)methyl)phenol (HL), which has been harnessed to generate complexes [Zn3L2(OAc)4] (1) and [Cd3L2(OAc)4] (2). X-ray single crystal diffraction studies unveil the trinuclear skeleton of complexes 1 and 2. Both complexes have been found to be highly fluorescent in nature. However, the quantum efficiency of Zn(II) complex (1) dominates over the Cd(II) analogue (2). The absorption and emission spectroscopic properties of the complexes have been investigated by density functional theory. Complexes 1 and 2 can detect Hg2+ ions selectively by fluorescence quenching, and it is noteworthy to mention that the mechanism of sensing is unique as well as interesting. In the presence of Hg2+ ions, complexes 1 and 2 are transformed to mononuclear mercuric intermediate complex (3) and finally to a trinuclear mercuric complex (4) by hydrolysis. We have successfully trapped the intermediate complex 3, and we characterized it with the aid of X-ray crystallography. Transformation of complexes 1 and 2 to intermediate complex 3 and finally to 4 has been established by UV-vis spectroscopy, fluorescence spectroscopy, ESI-MS spectroscopy, 1H NMR spectroscopy, and X-ray crystallography. The spontaneity of the above conversion is well supported by thermodynamic aspects as reflected from density functional theoretical calculations.