Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks. The microtissues and tissue spheroids are living materials with certain measurable, evolving and potentially controllable composition, material and biological properties. Closely placed tissue spheroids undergo tissue fusion - a process that represents a fundamental biological and biophysical principle of developmental biology-inspired directed tissue self-assembly. It is possible to engineer small segments of an intraorgan branched vascular tree by using solid and lumenized vascular tissue spheroids. Organ printing could dramatically enhance and transform the field of tissue engineering by enabling large-scale industrial robotic biofabrication of living human organ constructs with "built-in" perfusable intraorgan branched vascular tree. Thus, organ printing is a new emerging enabling technology paradigm which represents a developmental biology-inspired alternative to classic biodegradable solid scaffold-based approaches in tissue engineering.

Organ Printing: Tissue Spheroids as Building Blocks

Synthetic potential of the tertiary-amine-catalysed reaction of activated vinyl carbanions with aldehydes

This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013). A.G. (SFRH/BD/43531/2008) and M.J.M. (SFRH/BD/61262/2009) thank FCT for grants.

/pdf/chromone-a-valid-scaffold-in-medicinal-chemistry-4qd4v5m5z2.pdf

Chromone: A Valid Scaffold in Medicinal Chemistry

o-Quinone methides: intermediates underdeveloped and underutilized in organic synthesis

https://www.ircc.iitb.ac.in/IRCC-Webpage/rnd/PDF/Awards11KothaS.pdf

Kalpattu K. Balasubramanian

Papers

A Simple Synthesis of 3-Formyl-2H-chromenes

Studies on o-Quinonemethides; Part IV. Alkylation of Phenolic Mannich Bases with Aryl Phenacyl Sulfones

Synthesis of Wieland-Miescher Ketone Analogues-Potential Substrates for the Carbocyclic Frameworks

A Stereospecific Approach to cis-anti-cis Triquinanes

Acid activated montmorillonite K-10 mediated intramolecular acylation: Simple and convenient synthesis of 4-chromanones