Kalpattu K. Balasubramanian

Bio: Kalpattu K. Balasubramanian is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Aryl & Claisen rearrangement. The author has an hindex of 20, co-authored 139 publications receiving 1234 citations. Previous affiliations of Kalpattu K. Balasubramanian include University of Madras & Madurai Kamaraj University.

Synthesis of 5,6-Dihydrobenz[c]acridines: A Comparative Study.

Abstract: 5,6-Dihydrobenz[c]acridines were synthesized by the reaction of 1-chloro-3,4-dihydro-2-naphthaldehyde with aromatic amines under three different conditions: a. Thermolysis of 1-chlorovinyl-(N-aryl)imines prepared from 1-chloro-3,4-dihydro-2-naphthaldehyde. b. Acid catalyzed cyclization of 1-(N-aryl)amino-3,4-dihydro-2-naphthaldehydes. c. Thermolysis of N-arylenaminoimine hydrochlorides derived from 1-chloro-3,4-dihydro-2-naphthaldehyde in DMF medium. All the three approaches exclusively yielded only 5,6-dihydrobenz[c]acridines and not the isomeric 7,8-dihydrobenzo[k]phenanthridines. The structures of these products have been unambiguously established by detailed NMR spectral study and by independent synthesis as well as by single crystal XRD study.

Mild and Efficient Tetrahydropyranylation of Alcohols — Catalysis by Lithium Perchlorate in Diethyl Ether.

Abstract: Treatment of 3,4-dihydro-2 H -pyran 1 with various alcohols 2 – 10 furnished the tetrahydropyranyl ethers 11 – 19 in the presence of 5 M lithium perchlorate in diethyl ether (5 M LPDE), which is essentially a neutral medium.

Organ Printing: Tissue Spheroids as Building Blocks

Abstract: Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks. The microtissues and tissue spheroids are living materials with certain measurable, evolving and potentially controllable composition, material and biological properties. Closely placed tissue spheroids undergo tissue fusion - a process that represents a fundamental biological and biophysical principle of developmental biology-inspired directed tissue self-assembly. It is possible to engineer small segments of an intraorgan branched vascular tree by using solid and lumenized vascular tissue spheroids. Organ printing could dramatically enhance and transform the field of tissue engineering by enabling large-scale industrial robotic biofabrication of living human organ constructs with "built-in" perfusable intraorgan branched vascular tree. Thus, organ printing is a new emerging enabling technology paradigm which represents a developmental biology-inspired alternative to classic biodegradable solid scaffold-based approaches in tissue engineering.

Chromone: A Valid Scaffold in Medicinal Chemistry

Abstract: This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013). A.G. (SFRH/BD/43531/2008) and M.J.M. (SFRH/BD/61262/2009) thank FCT for grants.

Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco-compatible organic synthesis

Abstract: Multicomponent reactions have gained significant importance as a tool for the synthesis of a wide variety of useful compounds, including pharmaceuticals. In this context, the multiple component approach is especially appealing in view of the fact that products are formed in a single step, and the diversity can be readily achieved simply by varying the reacting components. The eco-friendly, solvent-free multicomponent approach opens up numerous possibilities for conducting rapid organic synthesis and functional group transformations more efficiently. Additionally, there are distinct advantages of these solvent-free protocols since they provide reduction or elimination of solvents thereby preventing pollution in organic synthesis “at source”. The chemo-, regio- or stereoselective synthesis of high-value chemical entities and parallel synthesis to generate a library of small molecules will add to the growth of multicomponent solvent-free reactions in the near future. In this review we summarized the results reported mainly within the last 10 years. It is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis. Therefore, diversity oriented synthesis (DOS) is rapidly becoming one of the paradigms in the process of modern drug discovery. This has spurred research in those fields of chemical investigation that lead to the rapid assembly of not only molecular diversity, but also molecular complexity. As a consequence multi-component as well as domino or related reactions are witnessing a new spring.