Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks. The microtissues and tissue spheroids are living materials with certain measurable, evolving and potentially controllable composition, material and biological properties. Closely placed tissue spheroids undergo tissue fusion - a process that represents a fundamental biological and biophysical principle of developmental biology-inspired directed tissue self-assembly. It is possible to engineer small segments of an intraorgan branched vascular tree by using solid and lumenized vascular tissue spheroids. Organ printing could dramatically enhance and transform the field of tissue engineering by enabling large-scale industrial robotic biofabrication of living human organ constructs with "built-in" perfusable intraorgan branched vascular tree. Thus, organ printing is a new emerging enabling technology paradigm which represents a developmental biology-inspired alternative to classic biodegradable solid scaffold-based approaches in tissue engineering.

Organ Printing: Tissue Spheroids as Building Blocks

Synthetic potential of the tertiary-amine-catalysed reaction of activated vinyl carbanions with aldehydes

This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013). A.G. (SFRH/BD/43531/2008) and M.J.M. (SFRH/BD/61262/2009) thank FCT for grants.

/pdf/chromone-a-valid-scaffold-in-medicinal-chemistry-4qd4v5m5z2.pdf

Chromone: A Valid Scaffold in Medicinal Chemistry

o-Quinone methides: intermediates underdeveloped and underutilized in organic synthesis

https://www.ircc.iitb.ac.in/IRCC-Webpage/rnd/PDF/Awards11KothaS.pdf

Transition Metal Catalyzed (2+2+2) Cycloaddition and Application in Organic Synthesis

Reaction of 1,5-anhydro-2-deoxy-2-formyl-3,4,6-tri-O-methyl-D-lyxo-hex-1-enitol 1 and its arabino epimer 3 with various nucleophiles under Lewis acid catalysis led to stereoselective C-3 substitution.

Stereoselective C-3 Substitution of 1,5-Anhydro-2-deoxy-2-formyl-3,4,6- tri-O-methylhex-1-enitols: Entry to ribo and xylo Series.

: A new aerophilic diatom species, Humidophila manipurensis sp. nov., is described from the Sadu Chiru waterfalls, Manipur, India, a part of the Indo–Burma hotspot region. This species is characterized by hav-ing its valve shape slightly inflated at middle, terminal raphe ends that are slightly deflected, round areolae and a central depression. Further, we also recorded Humidophila bigibba from Meghalaya State, Northeast India, and this population is compared with the type population from Indonesia and Chinese populations. Fine structural details of both taxa were examined using light and scanning electron microscopy and compared with morpho-logically similar taxa in this genus. Addition of new species from this region will further add to the biodiversity richness of the Indo–Burma biodiversity hotspot. Further, this study confirms the presence of H. bigibba for the first time in India. This species has a deep constriction in the middle of the valve which is not found in the populations from the Indonesia and China.

Humidophila manipurensis sp. nov. and the first record of Humidophila bigibba (Hustedt) Lange–Bertalot et Kopalová from Northeast India

The rearrangements of epimeric endo - and exo - dicyclopentadienyl vinyl ethers in lithium perchlorate in reported and the mechanism of the rearrangement in confirmed using deuterium labelling.

Lithium Perchlorate/Diethyl Ether-Induced Rearrangement of Epimeric endo- and exo-Dicyclopentadienyl Vinyl Ethers.

Photochemical Behavior of 3,4‐Epoxyprecocene‐I and Related Epoxychromans.

The photolysis of 4-methyl-3-(2-hydroxyphenyl)chrom-3-enes(1) in methanol at 300 nm affords 4b,9b-dihydro-4b, 9b-dimethylbenzofuro[3, 2-b]benzofurans (2), in good yield and the reaction rate is accelerated by sodium methoxide.

Kalpattu K. Balasubramanian

Papers

Stereoselective C-3 Substitution of 1,5-Anhydro-2-deoxy-2-formyl-3,4,6- tri-O-methylhex-1-enitols: Entry to ribo and xylo Series.

Humidophila manipurensis sp. nov. and the first record of Humidophila bigibba (Hustedt) Lange–Bertalot et Kopalová from Northeast India

Lithium Perchlorate/Diethyl Ether-Induced Rearrangement of Epimeric endo- and exo-Dicyclopentadienyl Vinyl Ethers.

Photochemical Behavior of 3,4‐Epoxyprecocene‐I and Related Epoxychromans.

Novel photochemical transformation of 4-methyl-2′-hydroxyisoflavenes to benzofuro(3,2-b)benzofurans