Kalpattu K. Balasubramanian

Bio: Kalpattu K. Balasubramanian is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Aryl & Claisen rearrangement. The author has an hindex of 20, co-authored 139 publications receiving 1234 citations. Previous affiliations of Kalpattu K. Balasubramanian include University of Madras & Madurai Kamaraj University.

A Stereospecific Approach to cis‐anti‐cis Triquinanes.

Abstract: A methodology for the synthesis of compounds containing the cis-anti-cis fused triquinane system has been developed starting from tricyclo[5.2.1.02,6]deca-4,8-dien-3-(exo)ol 6 involving Ireland ester Claisen rearrangement and intramolecular diazo ketone cyclopropanation reactions as key steps.

A Reinvestigation of the Claisen Rearrangement of Methyl γ‐Aryloxycrotonates. A Convenient Synthesis of 3‐Ethylidenebenzofuran‐2(3H)‐ones.

Abstract: The synthesis and Claisen rearrangement of methyl γ-aryloxycrotonates have been reinvestigated. A number of methyl γ-aryloxycrotonates have been prepared and sucessfully rearranged to a mixture of Z and E 3-ethylidenebenzofuran-2(3H)ones in refluxing ethylene glycol.

A New Route to o‐Allenylphenols.

Abstract: Cathodic reduction of 3-bromochromenes led to a ring-opening reaction yielding o-allenylphenyl acetates.

Electrochemical investigations on β-chlorovinylaldehydes in aprotic media

Abstract: The electrochemical study of β-chlorovinylaldehydes, namely, 4-chloro-3-formyl-2H (1)-benzopyran and β-chlorocinnamaldehyde was carried out in DMF in the presence of 0·1 M NBu4ClO4 as the supporting electrolyte. Both the depolarizers give three diffusionlimited polarographic waves and the corresponding cathodic peaks in cyclic voltammetry. Their microcoulometric data indicate a transfer of four-electrons (n app=4) in the electrode process. The macroscale controlled-potential electrolysis of the depolarizers afforded only blackish-brown tarry product. A mechanism is suggested for their reduction in DMF under polarographic conditions.

Organ Printing: Tissue Spheroids as Building Blocks

Abstract: Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks. The microtissues and tissue spheroids are living materials with certain measurable, evolving and potentially controllable composition, material and biological properties. Closely placed tissue spheroids undergo tissue fusion - a process that represents a fundamental biological and biophysical principle of developmental biology-inspired directed tissue self-assembly. It is possible to engineer small segments of an intraorgan branched vascular tree by using solid and lumenized vascular tissue spheroids. Organ printing could dramatically enhance and transform the field of tissue engineering by enabling large-scale industrial robotic biofabrication of living human organ constructs with "built-in" perfusable intraorgan branched vascular tree. Thus, organ printing is a new emerging enabling technology paradigm which represents a developmental biology-inspired alternative to classic biodegradable solid scaffold-based approaches in tissue engineering.

Chromone: A Valid Scaffold in Medicinal Chemistry

Abstract: This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013). A.G. (SFRH/BD/43531/2008) and M.J.M. (SFRH/BD/61262/2009) thank FCT for grants.

Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco-compatible organic synthesis

Abstract: Multicomponent reactions have gained significant importance as a tool for the synthesis of a wide variety of useful compounds, including pharmaceuticals. In this context, the multiple component approach is especially appealing in view of the fact that products are formed in a single step, and the diversity can be readily achieved simply by varying the reacting components. The eco-friendly, solvent-free multicomponent approach opens up numerous possibilities for conducting rapid organic synthesis and functional group transformations more efficiently. Additionally, there are distinct advantages of these solvent-free protocols since they provide reduction or elimination of solvents thereby preventing pollution in organic synthesis “at source”. The chemo-, regio- or stereoselective synthesis of high-value chemical entities and parallel synthesis to generate a library of small molecules will add to the growth of multicomponent solvent-free reactions in the near future. In this review we summarized the results reported mainly within the last 10 years. It is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis. Therefore, diversity oriented synthesis (DOS) is rapidly becoming one of the paradigms in the process of modern drug discovery. This has spurred research in those fields of chemical investigation that lead to the rapid assembly of not only molecular diversity, but also molecular complexity. As a consequence multi-component as well as domino or related reactions are witnessing a new spring.