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Kalpattu K. Balasubramanian

Bio: Kalpattu K. Balasubramanian is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Aryl & Claisen rearrangement. The author has an hindex of 20, co-authored 139 publications receiving 1234 citations. Previous affiliations of Kalpattu K. Balasubramanian include University of Madras & Madurai Kamaraj University.


Papers
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Journal ArticleDOI
TL;DR: One-pot chemo-, regio-, and stereoselective synthesis of series of heterocyclic and spiroheterocyclIC compounds was accomplished through mono- and bis[3 + 2]-cycloaddition reactions of (2E,4E)-ethyl 5-(phenylsulfonyl)penta-2,4-dienoate as a dipolarophile with azomethine ylides, nitrones, and nitrile oxides
Abstract: One-pot chemo-, regio-, and stereoselective synthesis of series of heterocyclic and spiroheterocyclic compounds was accomplished through mono- and bis[3 + 2]-cycloaddition reactions of (2E,4E)-ethyl 5-(phenylsulfonyl)penta-2,4-dienoate as a dipolarophile with azomethine ylides, nitrones, and nitrile oxides in good yields. The structures of the products were established by spectroscopic techniques as well as by single-crystal XRD study, and DFT calculations were performed to further understand the mechanism of this [3 + 2]-cycloaddition reaction.

14 citations

Journal ArticleDOI
22 Mar 2004-Synlett
TL;DR: In this article, a facile method for the synthesis of 2-cyclopentenones from the acid-catalysed fragmentation of 7,7-dimethoxy 5-norbornen-2-ols and their derivatives is reported.
Abstract: A facile method for the synthesis of 2-cyclopentenones from the acid catalysed fragmentation of 7,7-dimethoxy 5-norbornen-2-ols and their derivatives is reported.

14 citations

Journal ArticleDOI
TL;DR: In this paper, the rearrangements of epimeric endo -and exo -dicyclopentadienyl vinyl ethers in lithium perchlorate were reported.

13 citations

Journal ArticleDOI
TL;DR: In this paper, the rearrangement of 1,4-bis-aryloxybut-2-ynes to 4b,9b-dihydro-4b, 9b-dimethylbenzofuro (3,2-b) benzofuran is described.

12 citations

Journal ArticleDOI
TL;DR: A series of substituted 1-(2-arylmethyl-5-aryl-3-thienyl)pyrrolidines and piperidines were synthesized by one-pot, three-component tandem reactions of 5-aryldihydro-3(2 H )-thiophenone, aromatic aldehydes and pyrrolidine/piperidine under solvent-free microwave irradiation as discussed by the authors.

12 citations


Cited by
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01 Jan 2009
TL;DR: Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks.
Abstract: Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks. The microtissues and tissue spheroids are living materials with certain measurable, evolving and potentially controllable composition, material and biological properties. Closely placed tissue spheroids undergo tissue fusion - a process that represents a fundamental biological and biophysical principle of developmental biology-inspired directed tissue self-assembly. It is possible to engineer small segments of an intraorgan branched vascular tree by using solid and lumenized vascular tissue spheroids. Organ printing could dramatically enhance and transform the field of tissue engineering by enabling large-scale industrial robotic biofabrication of living human organ constructs with "built-in" perfusable intraorgan branched vascular tree. Thus, organ printing is a new emerging enabling technology paradigm which represents a developmental biology-inspired alternative to classic biodegradable solid scaffold-based approaches in tissue engineering.

942 citations

Journal ArticleDOI
TL;DR: In this paper, the diaza-1,4bicyclo [2.2] octane, la quinuclidine and ses derives, the quinine

621 citations

Journal ArticleDOI
TL;DR: This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013) and SFRH/BD/61262/2009.
Abstract: This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013). A.G. (SFRH/BD/43531/2008) and M.J.M. (SFRH/BD/61262/2009) thank FCT for grants.

514 citations

Journal ArticleDOI
TL;DR: In this paper, the authors summarized the results reported mainly within the last 10 years, and it is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis.
Abstract: Multicomponent reactions have gained significant importance as a tool for the synthesis of a wide variety of useful compounds, including pharmaceuticals. In this context, the multiple component approach is especially appealing in view of the fact that products are formed in a single step, and the diversity can be readily achieved simply by varying the reacting components. The eco-friendly, solvent-free multicomponent approach opens up numerous possibilities for conducting rapid organic synthesis and functional group transformations more efficiently. Additionally, there are distinct advantages of these solvent-free protocols since they provide reduction or elimination of solvents thereby preventing pollution in organic synthesis “at source”. The chemo-, regio- or stereoselective synthesis of high-value chemical entities and parallel synthesis to generate a library of small molecules will add to the growth of multicomponent solvent-free reactions in the near future. In this review we summarized the results reported mainly within the last 10 years. It is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis. Therefore, diversity oriented synthesis (DOS) is rapidly becoming one of the paradigms in the process of modern drug discovery. This has spurred research in those fields of chemical investigation that lead to the rapid assembly of not only molecular diversity, but also molecular complexity. As a consequence multi-component as well as domino or related reactions are witnessing a new spring.

420 citations