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Kalpita Baruah

Bio: Kalpita Baruah is an academic researcher from Shiv Nadar University. The author has contributed to research in topics: Amide & Peptide bond. The author has an hindex of 2, co-authored 5 publications receiving 16 citations.

Papers
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Journal ArticleDOI
TL;DR: It is shown that unusual N(amide)C-X noncovalent carbon bonding interactions stabilize the trans-cis (t-c) amide bond rotamers of N-methyl-N,N'-diacylhydrazines over the expected trans-trans ( t-t)rotamers.

13 citations

Journal Article
TL;DR: Additive genetic control for the characters leaf area, LAI and pulp: peel ratio was recorded as these parameters registered higher GA, heritability and GCV, indicating the suitability of these parameters for simple directional selection.
Abstract: An investigation was laid out to assess growth and yield performance of twenty banana cultivars and also to study the extent of genetic variation under Assam conditions. The performance study revealed that local cultivars of Assam viz., Bhutmanohar, Bharatmoni and Kachkal exhibited superiority in terms of growth parameters, while commercial cultivar Barjahaji was found most promising in terms of yield and yield attributing parameters. The highest GCV and corresponding PCV were observed in leaf area among growth parameters and in finger weight among yield attributing parameters indicating vast potential for genetic improvement of these two traits. Additive genetic control for the characters leaf area, LAI and pulp: peel ratio was recorded as these parameters registered higher GA, heritability and GCV. This indicates the suitability of these parameters for simple directional selection.

6 citations

Journal ArticleDOI
TL;DR: In this paper, an unusual Namide···H-Namide hydrogen bond (HB) was proposed to stabilize the azapeptide β-turns and showed that this HB endows a stabilization of 1-3 kcal·mol-1 and enforces the transcistrans (t-c-t) and cis-cis-trans (c-c -t) amide bond conformations in azAPEptides and N-methyl-azapeptides.

6 citations

Journal ArticleDOI
TL;DR: It is shown that different combinations of acylhydrazides, carbazates, semicarbazides, amino acids and primary amines can be used to synthesize highly diverse collection of hybrid DKP molecules via the solid-phase submonomer synthesis route.
Abstract: We report the solid-phase synthesis of N,N′-di(acylamino)-2,5-diketopiperazine, an acylhydrazide-based conformationally rigid 2,5-DKP scaffold having exocyclic N–N bonds. We also show that different combinations of acylhydrazides, carbazates, semicarbazides, amino acids, and primary amines can be used to synthesize a highly diverse collection of hybrid DKP molecules via the solid-phase submonomer synthesis route. Finally, we show incorporation of a methyl substituent in one of the carbon atoms of the DKP ring to generate chiral daa- and hybrid-DKPs without compromising the synthetic efficiency.

5 citations

Journal ArticleDOI
TL;DR: In this article, a modification of the Thioflavin T (ThT) structure via introduction of methyl and methoxy groups was described, and the effects of the substituents on fluorescence were investigated.
Abstract: New fluorescent molecular rotors (FMRs) were developed by modification of the Thioflavin T (ThT) structure via introduction of methyl and methoxy groups. Effects of the substituents on fluorescence...

1 citations


Cited by
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Journal ArticleDOI
TL;DR: Genetic diversity analysis was carried out in a set of forty-nine ginger clones cultivated in North-East India using random amplified polymorphic DNA (RAPD) markers, which supported grouping of the clones into six hypothetical populations based on their source or location of collection.

28 citations

Journal ArticleDOI
TL;DR: Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide counterparts as discussed by the authors.
Abstract: Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide counterparts. They have attracted great interest in a variety of fields spanning from functional materials to drug discovery. This concise review will analyze the latest advancements in their synthesis, self-assembly into gels, and their more innovative applications.

22 citations

Journal ArticleDOI
TL;DR: In this article, three aminobenzoate derivatives, benzocaine (B1), butamben (B2), and n-pentyl 4-aminobenzzoate (B3), were analyzed for structural, nonlinear optical, electronic and biological properties.

14 citations

Journal ArticleDOI
TL;DR: The properties of the derivatives provide new insights into the relationship between chemical structure and function of benzothiazole probes and their abilities to perform super-resolution imaging of α-synuclein fibrils with localisation precisions of ~16 nm.
Abstract: The benzothiazolium salt, Thioflavin T (ThT), has been widely adopted as the "gold-standard" fluorescent reporter of amyloid in vitro. Its properties as a molecular rotor result in a large-scale (∼1000-fold) fluorescence turn-on upon binding to β-sheets in amyloidogenic proteins. However, the complex photophysics of ThT combined with the intricate and varied nature of the amyloid binding motif means these interactions are poorly understood. To study this important class of fluorophores, we present a detailed photophysical characterization and comparison of a novel library of 12 ThT-inspired fluorescent probes for amyloid protein (PAPs), where both the charge and donor capacity of the heterocyclic and aminobenzene components have been interrogated, respectively. This enables direct photophysical juxtaposition of two structural groups: the neutral "PAP" (class 1) and the charged "mPAP" fluorophores (class 2). We quantify binding and optical properties at both the bulk and single-aggregate levels with some derivatives showing higher aggregate affinity and brightness than ThT. Finally, we demonstrate their abilities to perform super-resolution imaging of α-synuclein fibrils with localization precisions of ∼16 nm. The properties of the derivatives provide new insights into the relationship between chemical structure and function of benzothiazole probes.

10 citations

Journal ArticleDOI
TL;DR: This work presents the first example of sp3 hybridized carbon centered (Csp3) tetrel bonding mediated 3D BODIPY assembly via the exceptional synergy of Csp3⋯N and CSp3⊯F pair interactions.
Abstract: Here, we present the first example of sp3 hybridized carbon centered (Csp3) tetrel bonding mediated 3D BODIPY assembly via the exceptional synergy of Csp3⋯N and Csp3⋯F pair interactions. The carbon tetrel bond interaction energies of Csp3⋯N and Csp3⋯F are amplified significantly as the size of the 1D chain grows from dimer to tetramer BODIPY units.

9 citations