K
Kamal Rahmouni
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 195
Citations - 14176
Kamal Rahmouni is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Leptin & Leptin receptor. The author has an hindex of 55, co-authored 177 publications receiving 12209 citations. Previous affiliations of Kamal Rahmouni include Fraternal Order of Eagles & Veterans Health Administration.
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Journal ArticleDOI
Obesity-Associated Hypertension. New Insights Into Mechanisms
TL;DR: The continuing discovery of mechanisms regulating appetite and metabolism is likely to lead to new therapies for obesity-induced hypertension and better understanding of leptin signaling in the hypothalamus and the mechanisms of leptin resistance should facilitate therapeutic approaches to reverse the phenomenon of selective leptin resistance.
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A guide to analysis of mouse energy metabolism
Matthias H. Tschöp,John R. Speakman,John R. Speakman,Jonathan R.S. Arch,Johan Auwerx,Jens C. Brüning,Lawrence Chan,Robert H. Eckel,Robert V. Farese,Jose E. Galgani,Catherine Hambly,Mark A. Herman,Tamas L. Horvath,Barbara B. Kahn,Sara C. Kozma,Eleftheria Maratos-Flier,Timo D. Müller,Heike Münzberg,Paul T. Pfluger,Leona Plum,Marc L. Reitman,Kamal Rahmouni,Gerald I. Shulman,George Thomas,C. Ronald Kahn,Eric Ravussin +25 more
TL;DR: A consolidated view of the complexity and challenges of designing studies for measurement of energy metabolism in mouse models is presented, including a practical guide to the assessment of energy expenditure, energy intake and body composition and statistical analysis thereof.
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Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
Miguel López,Miguel López,Luis M. Varela,María J. Vázquez,Sergio Rodriguez-Cuenca,Carmen R. González,Vidya Velagapudi,Donald A. Morgan,Erik Schoenmakers,Khristofor Agassandian,Ricardo Lage,Pablo B. Martínez de Morentin,Sulay Tovar,Rubén Nogueiras,David Carling,Christopher J. Lelliott,Rosalía Gallego,Matej Orešič,Krishna Chatterjee,Asish K. Saha,Kamal Rahmouni,Carlos Dieguez,Antonio Vidal-Puig +22 more
TL;DR: Thyroid hormone–induced modulation of AMPK activity and lipid metabolism in the hypothalamus is a major regulator of whole-body energy homeostasis.
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BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions
Andrew J. Whittle,Stefania Carobbio,Luís Martins,Marc Slawik,Marc Slawik,Elayne Hondares,María Jesús Vázquez,Donald A. Morgan,Robert I. Csikasz,Rosalía Gallego,Sergio Rodriguez-Cuenca,Martin Dale,Samuel Virtue,Francesc Villarroya,Barbara Cannon,Barbara Cannon,Kamal Rahmouni,Miguel López,Antonio Vidal-Puig +18 more
TL;DR: The results indicate that BMP8B is a thermogenic protein that regulates energy balance in partnership with hypothalamic AMPK, and may offer a mechanism to specifically increase energy dissipation by BAT.
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FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss
Bryn M. Owen,Xunshan Ding,Donald A. Morgan,Katie C. Coate,Angie L. Bookout,Kamal Rahmouni,Steven A. Kliewer,David J. Mangelsdorf +7 more
TL;DR: It is reported that FGF21 acts centrally to exert its effects on energy expenditure and body weight in obese mice, and it is shown that βKlotho, the obligate coreceptor for FGF 21, is required in the nervous system for these effects.