K
Kamalika Moulick
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 14
Citations - 1198
Kamalika Moulick is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Chaperone (protein) & Apoptosis. The author has an hindex of 10, co-authored 14 publications receiving 1122 citations. Previous affiliations of Kamalika Moulick include Kettering University & University of North Carolina at Greensboro.
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Journal ArticleDOI
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models
Eloisi Caldas-Lopes,Leandro Cerchietti,James H. Ahn,Cristina C. Clement,Ana I. Robles,Anna Rodina,Kamalika Moulick,Tony Taldone,Alexander Gozman,Yunke Guo,Nian Wu,Elisa de Stanchina,Julie D. White,Steven S. Gross,Yuliang Ma,Lyuba Varticovski,Ari Melnick,Gabriela Chiosis +17 more
TL;DR: The results identify Hsp90 as a critical and multimodal target in this most difficult to treat breast cancer subtype and support the use of the Hsp 90 inhibitor PU-H71 for clinical trials involving patients with TNBC.
Journal ArticleDOI
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Wenjie Luo,Fei Dou,Anna Rodina,Sophorn Chip,Joungnam Kim,Qi Zhao,Kamalika Moulick,Julia Aguirre,Nian Wu,Paul Greengard,Gabriela Chiosis +10 more
TL;DR: P35, a neuronal protein that activates cyclin-dependent protein kinase 5 through complex formation leading to aberrant Tau phosphorylation, and that of mutant but not WT Tau protein is maintained in tauopathies by Hsp90, leading to a reduction of the pathogenic activity of these proteins and results in elimination of aggregated Tau.
Journal ArticleDOI
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90
Kamalika Moulick,James H. Ahn,Hongliang Zong,Anna Rodina,Leandro Cerchietti,Gomes-Dagama Erica M,Eloisi Caldas-Lopes,Kristin Beebe,Fabiana Perna,Katerina Hatzi,Ly P. Vu,Xinyang Zhao,Danuta Zatorska,Tony Taldone,Peter Smith-Jones,Mary L. Alpaugh,Steven S. Gross,Nagavarakishore Pillarsetty,Thomas Ku,Jason S. Lewis,Steven M. Larson,Ross L. Levine,Hediye Erdjument-Bromage,Monica L. Guzman,Stephen D. Nimer,Ari Melnick,Len Neckers,Gabriela Chiosis +27 more
TL;DR: This work uses PU-H71 affinity capture to design a proteomic approach that, when combined with bioinformatic pathway analysis, identifies dysregulated signaling networks and key oncoproteins in chronic myeloid leukemia and shows that this method can provide global insights into the biology of individual tumors, including primary patient specimens.
Journal ArticleDOI
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer
Anna Rodina,Maria Vilenchik,Maria Vilenchik,Kamalika Moulick,Julia Aguirre,Joungnam Kim,Anne C. Chiang,Julie Litz,Cristina C. Clement,Yanlong Kang,Yuhong She,Nian Wu,Sara J. Felts,Peter Wipf,Joan Massagué,Xuejun Jiang,Jeffrey L. Brodsky,Geoffrey W. Krystal,Gabriela Chiosis +18 more
TL;DR: It is discovered that small-cell lung carcinoma is a distinctive cellular system in which apoptosis is mainly regulated by Hsp90, and this results provide important evidence for a transformation-specific interplay between chaperones in regulating apoptosis in malignant cells.
Journal ArticleDOI
Design, synthesis, and evaluation of small molecule Hsp90 probes
Tony Taldone,Danuta Zatorska,Pallav D. Patel,Hongliang Zong,Anna Rodina,James H. Ahn,Kamalika Moulick,Monica L. Guzman,Gabriela Chiosis +8 more
TL;DR: The synthesis of chemical tools for three Hsp90 inhibitor classes will be useful for probing tumor-by-tumor the HSp90 complexes isolated by specific inhibitors, and will lead to better understanding of tumor specific molecular markers to aid in their clinical development.