Kanan Lathia

TL;DR: This study establishes a combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct areas of the adult mouse cortex and identifies 133 transcriptomic types of glutamatergic neurons to their long-range projection specificity.

TL;DR: RNA-sequencing analysis of cells in the human cortex enabled identification of diverse cell types, revealing well-conserved architecture and homologous cell types as well as extensive differences when compared with datasets covering the analogous region of the mouse brain.

TL;DR: A combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct regions of the mouse cortex is established and correspondence between excitatory transcriptomic types and their region-specific long-range target specificity is demonstrated.

TL;DR: It is demonstrated that closely related neuronal cell types can be similarly discriminated with both methods if intronic sequences are included in snRNA-seq analysis, and the high information content of nuclear RNA for characterization of cellular diversity in brain tissues is illustrated.

TL;DR: The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in perception, cognition, emotion, and learning as discussed by the authors, and a transcriptomic cell type taxonomy revealing a comprehensive repertoire of glutamatergic and GABAergic neuron types.