K
Kang Chen
Researcher at Wayne State University
Publications - 119
Citations - 7580
Kang Chen is an academic researcher from Wayne State University. The author has contributed to research in topics: Immunoglobulin class switching & Chemistry. The author has an hindex of 41, co-authored 106 publications receiving 6517 citations. Previous affiliations of Kang Chen include Cornell University & University of Pennsylvania.
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Journal ArticleDOI
Connexin mutations in X-linked Charcot-Marie-Tooth disease.
J Bergoffen,Steven S. Scherer,S. Wang,MO Scott,Linda Jo Bone,David L. Paul,Kang Chen,M. W. Lensch,Phillip F. Chance,Phillip F. Chance,Kenneth H. Fischbeck +10 more
TL;DR: Findings suggest that connexin32 plays an important role in peripheral nerve, a demonstration of inherited defects in a gap junction protein, in Charcot-Marie-Tooth disease.
Journal ArticleDOI
B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen
Irene Puga,Montserrat Cols,Carolina M. Barra,Bing-Yang He,Linda Cassis,Maurizio Gentile,Laura Comerma,Alejo Chorny,Meimei Shan,Weifeng Xu,Giuliana Magri,Daniel M. Knowles,Wayne Tam,April Chiu,James B. Bussel,Sergi Serrano,José Antonio Lorente,Beatriz Bellosillo,Josep Lloreta,Nuria Juanpere,Francesc Alameda,Teresa Baró,Cristina Díaz de Heredia,Nuria Toran,Albert Català,Montserrat Torrebadell,Claudia Fortuny,Victoria Cusí,Carmen Carreras,George A. Diaz,J. Magarian Blander,Claire-Michèle Farber,Guido Silvestri,Charlotte Cunningham-Rundles,Michaela Calvillo,Carlo Dufour,Lucia Dora Notarangelo,Vassilios Lougaris,Alessandro Plebani,Jean-Laurent Casanova,Stephanie C. Ganal,Andreas Diefenbach,Juan I. Aróstegui,Manel Juan,Jordi Yagüe,Nizar Mahlaoui,Jean Donadieu,Kang Chen,Andrea Cerutti +48 more
TL;DR: Neutrophils around the marginal zone (MZ) of the spleen, a B cell area specialized in T cell–independent immunoglobulin responses to circulating antigen, are identified, which indicates that neutrophils generate an innate layer of antimicrobial immunoglOBulin defense by interacting with MZ B cells.
Journal ArticleDOI
Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals
Meimei Shan,Maurizio Gentile,John R. Yeiser,A. Cooper Walland,Victor Ugarte Bornstein,Kang Chen,Kang Chen,Bing He,Linda Cassis,Anna Bigas,Montserrat Cols,Laura Comerma,Bihui Huang,J. Magarian Blander,Huabao Xiong,Lloyd Mayer,Cecilia Berin,Leonard H. Augenlicht,Anna Velcich,Andrea Cerutti +19 more
TL;DR: It is shown that the small intestine has a porous mucus layer, which permitted the uptake of MUC2 by antigen-sampling dendritic cells (DCs) and constrains the immunogenicity of gut antigens by delivering tolerogenic signals.
Journal ArticleDOI
Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell–stimulating programs in basophils
Kang Chen,Weifeng Xu,Melanie Wilson,Bing He,Norman W. Miller,Eva Bengtén,Eva-Stina Edholm,Paul A. Santini,Poonam Rath,April Chiu,Marco Cattalini,Jiri Litzman,James B. Bussel,Bihui Huang,Antonella Meini,Kristian Riesbeck,Charlotte Cunningham-Rundles,Alessandro Plebani,Andrea Cerutti +18 more
TL;DR: By showing dysregulation of IgD class–switched B cells and 'IgD-armed' basophils in autoinflammatory syndromes with periodic fever, the data indicate that IgD orchestrates an ancestral surveillance system at the interface between immunity and inflammation.
Journal ArticleDOI
Immunoglobulin Responses at the Mucosal Interface
TL;DR: Recent advances in understanding of the cellular interactions and signaling pathways governing IgA production at mucosal surfaces are reviewed and new findings on the regulation and function of mucosal IgD, the most enigmatic isotype of the mucosal antibody repertoire are discussed.