K
Kar Sian Lim
Researcher at Agency for Science, Technology and Research
Publications - 3
Citations - 1785
Kar Sian Lim is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Chromatin & Promoter. The author has an hindex of 3, co-authored 3 publications receiving 1616 citations.
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Journal ArticleDOI
An oestrogen-receptor-α-bound human chromatin interactome
Melissa J. Fullwood,Mei Hui Liu,You Fu Pan,Jun Liu,Han Xu,Yusoff Bin Mohamed,Yuriy L. Orlov,Stoyan Velkov,Andrea Ho,Poh Huay Mei,Elaine G.Y. Chew,Phillips Yao Hui Huang,Willem Welboren,Yuyuan Han,Hong Sain Ooi,Pramila N. Ariyaratne,Vinsensius B. Vega,Yanquan Luo,Peck Yean Tan,Pei Ye Choy,K. D. Senali Abayratna Wansa,Bing Zhao,Kar Sian Lim,Shi Chi Leow,Jit Sin Yow,Roy Joseph,Haixia Li,Kartiki V. Desai,Jane S. Thomsen,Yew Kok Lee,R. Krishna Murthy Karuturi,Thoreau Herve,Guillaume Bourque,Hendrik G. Stunnenberg,Xiaoan Ruan,Valere Cacheux-Rataboul,Wing-Kin Sung,Wing-Kin Sung,Edison T. Liu,Chia-Lin Wei,Edwin Cheung,Edwin Cheung,Edwin Cheung,Yijun Ruan,Yijun Ruan +44 more
TL;DR: It is proposed that chromatin interactions constitute a primary mechanism for regulating transcription in mammalian genomes and is described as a new strategy, chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) for the de novo detection of global Chromatin interactions.
Regulation of Estrogen Receptor-mediated Long Range Transcription via Evolutionarily Conserved Distal
You Fu Pan,Mei Hui Liu,Bing Zhao,Shuzhen Hong,Peck Yean Tan,Kar Sian Lim,Guillaume Bourque,Edison T. Liu,Edwin Cheung +8 more
TL;DR: In this article, the authors examined whether ER binding sites that are located distal from the transcription start sites of estrogen target genes are functionally relevant and found that ERs occupied at the distal sites are capable of communicating with ERs bound at the proximal promoter region, possibly via long range chromosome looping.
Journal ArticleDOI
Regulation of Estrogen Receptor-mediated Long Range Transcription via Evolutionarily Conserved Distal Response Elements
You Fu Pan,K. D. Senali Abayratna Wansa,Mei Hui Liu,Bing Zhao,Shuzhen Hong,Peck Yean Tan,Kar Sian Lim,Guillaume Bourque,Edison T. Liu,Edwin Cheung,Edwin Cheung,Edwin Cheung +11 more
TL;DR: The data indicate that distal ER binding sites are bona fide transcriptional enhancers that are involved in long range chromosomal interaction, transcription complex formation, and distinct structural modifications of chromatin across large genomic spans.