Karel Svoboda

Researcher at Howard Hughes Medical Institute

Publications - 267

Citations - 69970

Karel Svoboda is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Dendritic spine & Barrel cortex. The author has an hindex of 113, co-authored 250 publications receiving 60305 citations. Previous affiliations of Karel Svoboda include Stony Brook University & Watson School of Biological Sciences.

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Ultrasensitive fluorescent proteins for imaging neuronal activity.

Tsai Wen Chen, +14 more

- 18 Jul 2013 -

Nature

TL;DR: A family of ultrasensitive protein calcium sensors (GCaMP6) that outperformed other sensors in cultured neurons and in zebrafish, flies and mice in vivo are developed and provide new windows into the organization and dynamics of neural circuits over multiple spatial and temporal scales.

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Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex

Joshua T. Trachtenberg, +6 more

- 19 Dec 2002 -

Nature

TL;DR: The measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits.

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Journal ArticleDOI

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

Lin Tian, +14 more

- 08 Nov 2009 -

Nature Methods

TL;DR: A single-wavelength GCaMP2-based GECI (GCaMP3) is developed, with increased baseline fluorescence, increased dynamic range and higher affinity for calcium, and long-term imaging in the motor cortex of behaving mice revealed large fluorescence changes in imaged neurons over months.

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