K
Karel Ulbrich
Researcher at Academy of Sciences of the Czech Republic
Publications - 306
Citations - 19701
Karel Ulbrich is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Methacrylamide & Drug carrier. The author has an hindex of 72, co-authored 306 publications receiving 18594 citations. Previous affiliations of Karel Ulbrich include Czechoslovak Academy of Sciences & Keele University.
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Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies.
TL;DR: This review covers the principles, advantages, and drawbacks of passive and active targeting based on various polymer and magnetic iron oxide nanoparticle carriers with drug attached by both covalent and noncovalent pathways.
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Polymeric anticancer drugs with pH-controlled activation.
Karel Ulbrich,Vladimir Subr +1 more
TL;DR: Advances in development and study of properties of various acid-sensitive macromolecular drug delivery systems are reviewed, starting from simple polymer-drug conjugates to ending with site-specific antibody-targeted polymer- drug conjugate.
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Early Phase Tumor Accumulation of Macromolecules: A Great Difference in Clearance Rate between Tumor and Normal Tissues
Youichiro Noguchi,Jun Wu,Ruth Duncan,Jiří Strohalm,Karel Ulbrich,Takaaki Akaike,Hiroshi Maeda +6 more
TL;DR: The results suggest the “EPR effect” in solid tumor primarily arises from in the difference in clearance rate between the solid tumor and the normal tissues after initial penetration of the polymers into these tissues.
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Characterization of Vectors for Gene Therapy Formed by Self-Assembly of DNA with Synthetic Block Co-Polymers
Margreet A. Wolfert,Etienne Schacht,Veska Toncheva,Karel Ulbrich,Ola Nazarova,Leonard W. Seymour +5 more
TL;DR: A-B type cationic-hydrophilic block co-polymers are used to introduce a protective surface hydrophilic shielding following oriented self-assembly with DNA to permit design of materials for specific applications, including targeted delivery of genes in vivo.
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Polymeric micellar pH-sensitive drug delivery system for doxorubicin.
TL;DR: A novel polymeric micellar pH-sensitive system for delivery of doxorubicin (DOX) is described, which shows thatCleavage of hydrazone bonds between DOX and carrier continues even after plateau in the DOX release from micelles incubated in aqueous solutions is reached.