K
Karen Clark
Researcher at Harvard University
Publications - 1
Citations - 2503
Karen Clark is an academic researcher from Harvard University. The author has contributed to research in topics: Antigen processing & Peptide sequence. The author has an hindex of 1, co-authored 1 publications receiving 2434 citations.
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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
Kenneth L. Rock,Colette F. Gramm,Lisa Rothstein,Karen Clark,Ross L. Stein,Lawrence Dick,Daniel Hwang,Alfred L. Goldberg +7 more
TL;DR: Peptide aldehydes that inhibit major peptidase activities of the 20S and 26S proteasomes are shown to reduce the degradation of protein and ubiquitinated protein substrates by 26S particles.