Karen Fox-Talbot

TL;DR: The data show for the first time that nuclear miR-181c translocates into the mitochondria and regulates mitochondrial genome expression, ultimately causing electron transport chain complex IV remodeling and mitochondrial dysfunction.

TL;DR: The data show that antibody to host antigens can activate human endothelial cell exocytosis and leukocyte trafficking, and by triggering vascular inflammation, antibody activation of exocyTosis may play a role in transplant rejection.

TL;DR: Intramuscular injection of AdCA5 into the ischemic limb of db/db mice increased the recovery of limb perfusion and function, reduced tissue necrosis, rescued the diabetes-associated impairment of circulating angiogenic cells, enhanced endothelial nitric oxide synthase activation, and increased vessel density and luminal area in the isChemic limb.

TL;DR: It is reported that Hif1af/f;Tie2-Cre conditional knockout mice, which lack HIF-1α expression only in Tie2+ lineage cells, develop normally, but when subjected to pressure overload induced by transaortic constriction, they manifest rapid cardiac decompensation.

TL;DR: EC miRNA expression levels are generally consistent across EC types, and polycistronic miRNA chromosomal clusters have common expression levels within a given cell type.