K
Karen N. Conneely
Researcher at Emory University
Publications - 146
Citations - 13236
Karen N. Conneely is an academic researcher from Emory University. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 45, co-authored 135 publications receiving 11190 citations. Previous affiliations of Karen N. Conneely include Cincinnati Children's Hospital Medical Center & University of Michigan.
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Journal ArticleDOI
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
Laura J. Scott,Karen L. Mohlke,Lori L. Bonnycastle,Cristen J. Willer,Yun Li,William L. Duren,Michael R. Erdos,Heather M. Stringham,Peter S. Chines,Anne U. Jackson,Ludmila Prokunina-Olsson,Chia-Jen Ding,Amy J. Swift,Narisu Narisu,Tianle Hu,Randall Pruim,Rui Xiao,Xiao-Yi Li,Karen N. Conneely,Nancy Riebow,Andrew G. Sprau,Maurine Tong,Peggy P. White,Kurt N. Hetrick,Michael W. Barnhart,Craig W. Bark,Janet L. Goldstein,Lee Watkins,Fang Xiang,Jouko Saramies,Thomas A. Buchanan,Richard M. Watanabe,Timo T. Valle,Leena Kinnunen,Gonçalo R. Abecasis,Elizabeth W. Pugh,Kimberly F. Doheny,Richard N. Bergman,Jaakko Tuomilehto,Francis S. Collins,Michael Boehnke +40 more
TL;DR: The number of T2D loci now confidently identified to at least 10 is confirmed, and it is confirmed that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T1D risk.
Journal ArticleDOI
Epigenetic Signatures of Cigarette Smoking
Roby Joehanes,Allan C. Just,Riccardo E. Marioni,Luke C. Pilling,Lindsay M. Reynolds,Pooja R. Mandaviya,Weihua Guan,Tao Xu,Cathy E. Elks,Stella Aslibekyan,Hortensia Moreno-Macías,Jennifer A. Smith,Jennifer A. Brody,Radhika Dhingra,Paul Yousefi,James S. Pankow,Sonja Kunze,Sonia Shah,Allan F. McRae,Kurt Lohman,Jin Sha,Jin Sha,Devin Absher,Luigi Ferrucci,Wei Zhao,Ellen W. Demerath,Jan Bressler,Megan L. Grove,Tianxiao Huan,Tianxiao Huan,Chunyu Liu,Chunyu Liu,Chunyu Liu,Michael M. Mendelson,Chen Yao,Douglas P. Kiel,Annette Peters,Rui Wang-Sattler,Peter M. Visscher,Naomi R. Wray,John M. Starr,Jingzhong Ding,Carlos J. Rodriguez,Nicholas J. Wareham,Marguerite R. Irvin,Degui Zhi,Myrto Barrdahl,Paolo Vineis,Srikant Ambatipudi,André G. Uitterlinden,Albert Hofman,Joel Schwartz,Elena Colicino,Lifang Hou,Pantel S. Vokonas,D. Hernandez,Andrew B. Singleton,Stefania Bandinelli,Stephen Turner,Erin B. Ware,Alicia K. Smith,Torsten Klengel,Elisabeth B. Binder,Bruce M. Psaty,Kent D. Taylor,Sina A. Gharib,Brenton R. Swenson,Liming Liang,Dawn L. DeMeo,George T. O'Connor,Zdenko Herceg,Kerry J. Ressler,Karen N. Conneely,N. Sotoodehnia,Sharon L.R. Kardia,David Melzer,Andrea A. Baccarelli,Joyce B. J. van Meurs,Isabelle Romieu,Donna K. Arnett,Ken K. Ong,Yongmei Liu,M. Waldenberger,Ian J. Deary,Myriam Fornage,Daniel Levy,Stephanie J. London +86 more
TL;DR: Cigarette smoking has a broad impact on genome-wide methylation that, at many loci, persists many years aftersmoking cessation, indicating a pattern of persistent altered methylation, with attenuation, after smoking cessation.
Journal ArticleDOI
Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder
Divya Mehta,Torsten Klengel,Karen N. Conneely,Alicia K. Smith,Andre Altmann,Thaddeus W.W. Pace,Monika Rex-Haffner,Anne Loeschner,Mariya Gonik,Kristina B. Mercer,Bekh Bradley,Bertram Müller-Myhsok,Kerry J. Ressler,Kerry J. Ressler,Kerry J. Ressler,Elisabeth B. Binder,Elisabeth B. Binder +16 more
TL;DR: The findings that nonoverlapping biological pathways seem to be affected in the two PTSD groups and that changes in DNA methylation appear to have a much greater impact in the childhood-abuse group might reflect differences in the pathophysiology of PTSD, in dependence of exposure to childhood maltreatment.
Journal ArticleDOI
The transcriptional landscape of age in human peripheral blood
Marjolein J. Peters,Roby Joehanes,Luke C. Pilling,Claudia Schurmann,Claudia Schurmann,Karen N. Conneely,Joseph E. Powell,Eva Reinmaa,George L. Sutphin,Alexandra Zhernakova,Katharina Schramm,Yana A. Wilson,Sayuko Kobes,Taru Tukiainen,Taru Tukiainen,Yolande F. M. Ramos,Harald H H Göring,Myriam Fornage,Yongmei Liu,Sina A. Gharib,Barbara E. Stranger,Philip L. De Jager,Abraham Aviv,Daniel Levy,Joanne M. Murabito,Peter J. Munson,Tianxiao Huan,Albert Hofman,André G. Uitterlinden,Fernando Rivadeneira,Jeroen van Rooij,Lisette Stolk,Linda Broer,Michael M. P. J. Verbiest,Mila Jhamai,Pascal P. Arp,Andres Metspalu,Liina Tserel,Lili Milani,Nilesh J. Samani,Nilesh J. Samani,Pärt Peterson,Silva Kasela,Veryan Codd,Veryan Codd,Annette Peters,Cavin K. Ward-Caviness,Christian Herder,Melanie Waldenberger,Michael Roden,Paula Singmann,Sonja Zeilinger,Thomas Illig,Georg Homuth,Hans J. Grabe,Henry Völzke,Leif Steil,Thomas Kocher,Anna Murray,David Melzer,Hanieh Yaghootkar,Stefania Bandinelli,Eric K. Moses,Jack W. Kent,Joanne E. Curran,Matthew P. Johnson,Sarah Williams-Blangero,Harm-Jan Westra,Harm-Jan Westra,Harm-Jan Westra,Allan F. McRae,Jennifer A. Smith,Sharon L.R. Kardia,Iiris Hovatta,Iiris Hovatta,Markus Perola,Markus Perola,Markus Perola,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Veikko Salomaa,Anjali K. Henders,Nicholas G. Martin,Alicia K. Smith,Divya Mehta,Elisabeth B. Binder,K. Maria Nylocks,Elizabeth M. Kennedy,Torsten Klengel,Jingzhong Ding,Astrid Suchy-Dicey,Daniel A. Enquobahrie,Jennifer A. Brody,Jerome I. Rotter,Yii-Der Ida Chen,Jeanine J. Houwing-Duistermaat,Margreet Kloppenburg,P. Eline Slagboom,Quinta Helmer,Wouter den Hollander,Shannon Bean,Towfique Raj,Noman Bakhshi,Qiao-Ping Wang,Lisa J. Oyston,Bruce M. Psaty,Bruce M. Psaty,Russell P. Tracy,Grant W. Montgomery,Stephen T. Turner,John Blangero,Ingrid Meulenbelt,Kerry J. Ressler,Jian Yang,Lude Franke,Johannes Kettunen,Johannes Kettunen,Johannes Kettunen,Peter M. Visscher,G. Gregory Neely,Ron Korstanje,Robert L. Hanson,Holger Prokisch,Luigi Ferrucci,Tõnu Esko,Tõnu Esko,Tõnu Esko,Alexander Teumer,Joyce B. J. van Meurs,Andrew D. Johnson,Mike A. Nalls,Dena G. Hernandez,Dena G. Hernandez,Mark R. Cookson,Raphael Gibbs,Raphael Gibbs,John Hardy,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Alan B. Zonderman,Allissa Dillman,Allissa Dillman,Bryan J. Traynor,Colin Smith,Dan L. Longo,Daniah Trabzuni,Daniah Trabzuni,Juan C. Troncoso,Marcel P. van der Brug,Marcel P. van der Brug,Michael E. Weale,Richard O'Brien,Robert L. Johnson,Robert Walker,Ronald H. Zielke,Sampath Arepalli,Mina Ryten,Andrew B. Singleton +158 more
TL;DR: Differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index and the transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models.
Journal ArticleDOI
So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests.
TL;DR: A method of computing P values adjusted for correlated tests (P(ACT)) that attains the accuracy of permutation or simulation-based tests in much less computation time is presented and it is shown that the method applies to many common association tests that are based on multiple traits, markers, and genetic models.