K
Karen S. Anderson
Researcher at Yale University
Publications - 328
Citations - 16448
Karen S. Anderson is an academic researcher from Yale University. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 60, co-authored 308 publications receiving 14402 citations. Previous affiliations of Karen S. Anderson include Arizona State University & Duke University.
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Journal ArticleDOI
Molecular Definition of Breast Tumor Heterogeneity
Michail Shipitsin,Lauren L. Campbell,Pedram Argani,Stanislawa Weremowicz,Noga Bloushtain-Qimron,Jun Yao,Tatiana Nikolskaya,Tatiana Serebryiskaya,Rameen Beroukhim,Min Hu,Marc K. Halushka,Saraswati Sukumar,Leroy M. Parker,Karen S. Anderson,Lyndsay Harris,Judy Garber,Andrea L. Richardson,Stuart J. Schnitt,Yuri Nikolsky,Rebecca Gelman,Kornelia Polyak +20 more
TL;DR: In this paper, gene expression and genetic profiles of cells purified from cancerous and normal breast tissue using markers previously associated with stem-cell-like properties were determined using markers from the TGF-β pathway, where its inhibition induced a more epithelial phenotype.
Journal ArticleDOI
The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors
Lauren L. C. Marotta,Vanessa Almendro,Vanessa Almendro,Andriy Marusyk,Michail Shipitsin,Janina Schemme,Sarah R. Walker,Noga Bloushtain-Qimron,Jessica J. Kim,Sibgat Choudhury,Reo Maruyama,Zhenhua Wu,Mithat Gonen,Laura Mulvey,Marina Bessarabova,Sung Jin Huh,Serena J. Silver,So Young Kim,So Young Kim,So Yeon Park,Hee Eun Lee,Karen S. Anderson,Andrea L. Richardson,Tatiana Nikolskaya,Yuri Nikolsky,X. Shirley Liu,David E. Root,William C. Hahn,William C. Hahn,David A. Frank,Kornelia Polyak +30 more
TL;DR: The IL-6/JAK2/Stat3 pathway was preferentially active in CD44+CD24- breast cancer cells compared with other tumor cell types, and inhibition of JAK2 decreased their number and blocked growth of xenografts.
Journal ArticleDOI
CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3
Jingqi Chen,Jingqi Chen,Yandan Yao,Chang Gong,Fengyan Yu,Shicheng Su,Jianing Chen,Bodu Liu,Hui Deng,Fengsong Wang,Ling Lin,Herui Yao,Fengxi Su,Karen S. Anderson,Qiang Liu,Qiang Liu,Mark E. Ewen,Xuebiao Yao,Erwei Song +18 more
TL;DR: In this article, the authors show that breast TAMs abundantly produce CCL18, and its expression in blood or cancer stroma is associated with metastasis and reduced patient survival.
Journal ArticleDOI
Direct-drive inertial confinement fusion: A review
R. S. Craxton,Karen S. Anderson,T. R. Boehly,Valeri Goncharov,D. R. Harding,J. P. Knauer,R. L. McCrory,P. W. McKenty,D. D. Meyerhofer,J.F. Myatt,Andrew J. Schmitt,John D. Sethian,R. W. Short,S. Skupsky,W. Theobald,William L. Kruer,Kazuo Tanaka,Riccardo Betti,Tim Collins,J. A. Delettrez,Suxing Hu,J. A. Marozas,A. V. Maximov,D. T. Michel,P. B. Radha,Sean Regan,T. C. Sangster,W. Seka,A. A. Solodov,J. M. Soures,Christian Stoeckl,Jonathan D. Zuegel +31 more
TL;DR: The direct-drive, laser-based approach to inertial confinement fusion (ICF) is reviewed from its inception following the demonstration of the first laser to its implementation on the present generation of high-power lasers as mentioned in this paper.
Journal ArticleDOI
Presentation of viral antigen controlled by a gene in the major histocompatibility complex.
Vincenzo Cerundolo,J Alexander,Karen S. Anderson,C Lamb,Peter Cresswell,Andrew J. McMichael,Frances M. Gotch,Alain Townsend +7 more
TL;DR: A mutant human cell line is described that has lost a function required for presentation of intracellular viral antigens with class I molecules of the major histocompatibility complex (MHC), but retains the capacity to present defined epitopes as extracellular peptides.