K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
Vascular endothelial growth factor C induces angiogenesis in vivo
Yihai Cao,Philip A. Linden,Jacob Farnebo,Renhai Cao,Anna Eriksson,Vijay Kumar,Jian Hua Qi,Lena Claesson-Welsh,Kari Alitalo +8 more
TL;DR: VEGF-C may regulate physiological angiogenesis and participate in the development and progression of angiogenic diseases in addition to lymphangiogenesis, and is sufficiently potent to stimulate neovascularization from limbal vessels in the mouse cornea.
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Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells.
Birgitta Olofsson,Eija Korpelainen,Michael S. Pepper,Stefano J. Mandriota,Karin Aase,Vijay Kumar,Yuji Gunji,Michael Jeltsch,Masabumi Shibuya,Kari Alitalo,Ulf Eriksson +10 more
TL;DR: The binding of VEGF-B to its receptor on endothelial cells leads to increased expression and activity of urokinase type plasminogen activator and plasmineg activator inhibitor 1, suggesting a role for VEGf-B in the regulation of extracellular matrix degradation, cell adhesion, and migration.
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VEGFR-3 and Its Ligand VEGF-C Are Associated with Angiogenesis in Breast Cancer
Reija Valtola,Petri Salven,Päivi Heikkilä,Jussi Taipale,Heikki Joensuu,Marko Rehn,Taina Pihlajaniemi,Herbert A. Weich,Robert deWaal,Kari Alitalo +9 more
TL;DR: The results suggest that VEGF-C secreted by the intraductal carcinoma cells acts predominantly as an angiogenic growth factor for blood vessels, although this paracrine signaling network between the cancer cells and the endothelium may also be involved in modifying the permeabilities of both blood and lymphatic vessels and metastasis formation.
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Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development
Daniel J. Dumont,Guo-Hua Fong,Mira C. Puri,Mira C. Puri,Gérard Gradwohl,Kari Alitalo,Martin L. Breitman,Martin L. Breitman +7 more
TL;DR: A possible dual role for VEGF which includes a chemotactic and/or a cellular maintenance role forVEGF during vascularization of the mouse embryo is suggested.
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Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
Peter Baluk,Tuomas Tammela,Erin Ator,Natalya Lyubynska,Marc G. Achen,Daniel J. Hicklin,Michael Jeltsch,Tatiana V. Petrova,Bronislaw Pytowski,Steven A. Stacker,Seppo Ylä-Herttuala,David A. Jackson,Kari Alitalo,Donald M. McDonald +13 more
TL;DR: It is suggested that when lymphangiogenesis is impaired, airway inflammation may lead to bronchial lymphedema and exaggerated airflow obstruction, and Correction of defective lymphang iogenesis may benefit the treatment of asthma and other inflammatory airway diseases.