Kari Alitalo

TL;DR: It is demonstrated that neutralization of Ang2 prevents EC activation, leukocyte infiltration, Tx‐IRI and the development of chronic rejection in rat cardiac allografts.

TL;DR: Of the growth factors tested, PlGF emerged as the most efficient and safe angiogenic factor, hence making it a candidate for therapeutic CNS revascularization.

TL;DR: Comparisons with cells synchronized by serum starvation showed that in both cell lines the nucleosomal organization of chromatin is relatively condensed at the quiescent state, becomes highly decondensed during the late G1 phase of the cell cycle, and starts again to condense during the S phase, however, in ras-transformed cells the decondensation state stayed much longer than in normal cells.

TL;DR: Evidence is provided of VEGF-C as a neurotrophic factor that influences the dopaminergic system through multiple mechanisms and activation of astroglia and microglia as well as blood-brain barrier disruption after intracerebral delivery of VPD, raising a concern of its safe usage as a therapeutic molecule.

TL;DR: These studies support the proposed role of laminin in the adhesion of epidermal cells to basement membrane collagen in experimentally induced skin blisters.