K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Simultaneous targeting of VEGF-receptors 2 and 3 with immunoliposomes enhances therapeutic efficacy
Annette Orleth,Christoph Mamot,Christoph Rochlitz,Reto Ritschard,Kari Alitalo,Gerhard Christofori,Andreas Wicki +6 more
TL;DR: Nanoparticles against VEGFR2 and −3 expressing tumor-associated endothelial cells represent a promising and novel anti-cancer strategy that leads to tumor starvation and pronounced reduction of tumor burden.
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c-Myc and E1A induced cellular sensitivity to activated NK cells involves cytotoxic granules as death effectors.
Juha Klefström,Panu E. Kovanen,Kristina Somersalo,Anne-Odile Hueber,Trevor D. Littlewood,Gerard I. Evan,Arnold H. Greenberg,Eero Saksela,Tuomo Timonen,Kari Alitalo +9 more
TL;DR: Evidence is provided that c-Myc and E1A activated the NK cell induced cytolysis at a post-triggering stage of NK cell-target cell interaction, indicating that oncogenes activate the cytotoxicity ofNK cell granules.
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Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem-like Cells.
Jenny Högström,Sarika Heino,Pauliina Kallio,Marianne Lähde,Veli-Matti Leppänen,Diego Balboa,Zoltán Wiener,Kari Alitalo +7 more
TL;DR: It is reported that in LGR5+ colorectal cancer cells, PROX1 suppresses the Notch pathway, which is essential for cell fate in intestinal stem cells and helps to enforce the stem cell phenotype and inhibit differentiation.
Journal ArticleDOI
Short and Long-Term Effects of hVEGF-A165 in Cre-Activated Transgenic Mice
Pia Leppänen,Ivana Kholová,Anssi J. Mähönen,Kari J. Airenne,Suvi Koota,Hannu Mansukoski,Johanna Närväinen,Maria Wirzenius,Leena Alhonen,Juhani Jänne,Kari Alitalo,Seppo Ylä-Herttuala +11 more
TL;DR: It is concluded that long-term uncontrolled hVEGF-A165 expression in only a limited number of target cells in adult mice can be associated with pathological changes, including possible formation of malignant tumors and uncontrolled bleeding in target tissues.