K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
Assessment of tumour viability in human lung cancer xenografts with texture-based image analysis
Riku Turkki,Nina Linder,Tanja Holopainen,Yinhai Wang,Anne Grote,Mikael Lundin,Kari Alitalo,Johan Lundin +7 more
TL;DR: The proposed image analysis-based tumour viability assessment resulted in a high agreement with expert annotations, and can be used in preclinical research settings by providing extraction of detailed information of the tumour microenvironment.
Journal ArticleDOI
Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance
Sinem Yeles Karaman,Satu Paavonsalo,Krista Heinolainen,Madeleine H. Lackman,Amanda Ranta,Karthik Amudhala Hemanthakumar,Yoshiaki Kubota,Kari Alitalo +7 more
TL;DR: Using VEGF receptor deletions in mice, the authors show that VEGFR1 and V EGFR3 can support vessel maintenance in the absence of VEG FR2 in an organ-specific manner in postnatal and adult mice.
Journal ArticleDOI
Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium
Johanna Lähteenvuo,Olli-Pekka Hätinen,Antti Kuivanen,Jenni Huusko,Jussi Paananen,Markku Lähteenvuo,Jussi Nurro,Marja Hedman,Juha Hartikainen,Nihay Laham-Karam,Petri I. Mäkinen,Markus Räsänen,Kari Alitalo,Anthony Rosenzweig,Seppo Ylä-Herttuala +14 more
TL;DR: High AdVEGF-B186 overexpression induced nerve growth in the adult heart via a VEGFR-1 signaling-independent mechanism, leading to an increased risk of VA and sudden cardiac death.
Book ChapterDOI
Lymphangiogenesis in development and disease.
TL;DR: Understanding of how the lymphatic endothelial cells differentiate, how lymphatic vessel growth is regulated and how the remodelling of theymphatic vasculature into a functional vessel network consisting of capillaries and collecting vessels occurs is greatly increased.
Journal ArticleDOI
Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant
Ravi Kant,Lauri Kareinen,Teemu Smura,Tobias L. Freitag,Sawan Kumar Jha,Kari Alitalo,Seppo Meri,Tarja Sironen,Kalle Saksela,Tomas Strandin,Anja Kipar,Anja Kipar,Anja Kipar,Olli Vapalahti +13 more
TL;DR: In this article, the SARS-CoV-2 beta variant attains infectibility to BALB/c mice and causes pulmonary changes within 2-3 days post infection, consistent with results seen in other murine models of COVID-19.