K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
Papers
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Transforming growth factor-beta does not alter interleukin-1 expression in cultured human macrophages.
TL;DR: The results show that the TGF β used was biologically active but they provide no evidence for TGFβ in the regulation of IL‐1 production in human monocytes.
Patent
Expression vectors and cell lines expressing vascular endothelial growth factor D
TL;DR: In this article, a method for treating and alleviating melanomas or tumors expressing VEGF-D and various diseases was proposed, which relates to expression vectors comprising VEGFs and its biologically active derivatives, cell lines stably expressing VegFs and their derivatives, and to a method of making a polypeptide using these expression vectors and host cells.
Journal ArticleDOI
RFLPs in the fibroblast growth factor receptor-4 locus (FGFR4) in 5q33-qter
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Ex vivo intracoronary gene transfer of adeno-associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants
Alireza Raissadati,Janne J. Jokinen,Simo Syrjälä,M.A.I. Keranen,Rainer Krebs,R. Tuuminen,Ralica Arnaudova,Eeva Rouvinen,Andrey Anisimov,Jarkko Soronen,Katri Pajusola,Kari Alitalo,Antti I. Nykänen,Karl B. Lemström +13 more
TL;DR: Results suggest AAV2 as a potential vector for gene therapy in preclinical heart transplants studies, and highlight the importance of delivery route in gene transfer studies.
Journal Article
VEGFR-3 mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
Yulong He,Iiro Rajantie,Katri Pajusola,Seppo Ylä-Herttuala,Thomas Harding,Karin Jooss,Takashi Takahashi,Kari Alitalo +7 more
TL;DR: It is concluded that angiogenesis induced by colorectal carcinoma cells is regulated by Src kinase and that heterogeneous endothelial cells from distinct anatomic sites may be differentially activated by coloresceptic cancer cells.