K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
Blocking Angiopoietin-2 Promotes Vascular Damage and Growth Inhibition in Mouse Tumors Treated with Small Doses of Radiation
Pauliina Kallio,Elina Jokinen,Jenny Högström,Suvendu Das,Sarika Heino,Marianne Lähde,Jefim Brodkin,Emilia A. Korhonen,Kari Alitalo +8 more
TL;DR: Combination treatment with anti-Ang2 and radiation improved tumor growth inhibition and extended the survival of mice with melanoma or colorectal tumors and Ang2 blocking rescued radiation-induced decreases in T cells and cells of the monocyte/macrophage lineage.
Journal ArticleDOI
Inside bloody lymphatics.
Gabriela D'Amico,Kari Alitalo +1 more
TL;DR: Lymphatic vessels were missed by many pathologists for centuries because they do not contain red blood cells, but the reason for this has been illuminated only now in several articles in Blood.
Journal ArticleDOI
Functional MRI Measurements to Predict Early Adenoviral Gene Therapy Response in Ovarian Cancer Mouse Model
Laura Tuppurainen,Hanna Sallinen,Hanne Hakkarainen,Timo Liimatainen,Hassan M,Elias Ylä-Herttuala,Maarit Anttila,Kirsi Hämäläinen,Veli-Matti Kosma,Seppo Heinonen,Kari Alitalo,Seppo Ylä-Herttuala +11 more
TL;DR: Early changes in T2 relaxation times and ADC values after gene therapy suggest the potential of T1 relaxation time measurements and DW-MRI as early markers of treatment response after anti-angiogenic gene therapy and chemotherapy.
Book ChapterDOI
Five FGF receptors with distinct expression patterns.
Jaana Korhonen,Juha Partanen,Elina Eerola,Satu Vainikka,Riitta Alitalo,Tomi P. Mäkelä,Minna Sandberg,Harri Hirvonen,Kari Alitalo +8 more
TL;DR: The fibroblast growth factors (FGF) constitute a polypeptide family whose members can interact with cell surface receptors to modulate gene expression for cell proliferation and differentiation.
Journal ArticleDOI
Phase 1 Lymfactin® Study: 24-month Efficacy and Safety Results of Combined Adenoviral VEGF-C and Lymph Node Transfer Treatment for Upper Extremity Lymphedema.
Ida-Maria Leppäpuska,Pauliina Hartiala,Sinikka Suominen,Erkki Suominen,Ilkka Kaartinen,Maija Mäki,Marko Seppänen,Juha Kiiski,Tiina P. Viitanen,Outi Lahdenperä,Antti Vuolanto,Kari Alitalo,Anne Saarikko +12 more
TL;DR: Lymfactin® was combined with microvascular lymph node transfer surgery (VLNT) to study the safety and efficacy of the treatment in breast cancer-related upper limb lymphedema (BCRL) patients as mentioned in this paper .