K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal Article
Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14.
Domenico Maglione,Guerriero,Giuseppe Viglietto,Ferraro Mg,Olga Aprelikova,Kari Alitalo,Del Vecchio S,Lei Kj,Chou Jy,M. G. Persico +9 more
TL;DR: Preliminary results indicate that the PIGF gene has been conserved in evolution, since the human PlGF cDNA hybridizes to sequences present in the genomic DNA of Drosophila, Xenopus, chicken and mouse.
Journal ArticleDOI
VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues
Taina A. Partanen,Johanna Arola,Anne Saaristo,Lotta Jussila,Ari Ora,Markku Miettinen,Steven A. Stacker,Marc G. Achen,Kari Alitalo +8 more
TL;DR: The results suggest that V EGF‐C and VEGF‐D have a paracrine function and perhaps a role in peptide release from secretory granules of certain neuroendocrine cells to surrounding capillaries.
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Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers.
Steven A. Stacker,Kaye L. Stenvers,Carol Caesar,Angela A. Vitali,Teresa Domagala,Edouard C. Nice,Sally Roufail,Richard J. Simpson,Robert L. Moritz,Terhi Karpanen,Kari Alitalo,Marc G. Achen +11 more
TL;DR: It is reported that VEGF-D is proteolytically processed to release the VHD, which is predominantly a non-covalent dimer and in situ hybridization demonstrated that embryonic lung is a major site of expression of the VEGf-D gene.
Journal Article
FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.
Katri Pajusola,Olga Aprelikova,Jaana Korhonen,Arja Kaipainen,Liisa Pertovaara,Riitta Alitalo,Kari Alitalo +6 more
TL;DR: The fms-like tyrosine kinase 4 (FLT4) complementary DNA was cloned from a human HEL erythroleukemia cell library by polymerase chain reaction-amplification and the full-length sequence of the predicted FLT4 protein is presented.
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Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution
Raghu P. Kataru,Keehoon Jung,Cholsoon Jang,Hanseul Yang,Reto A. Schwendener,Jung Eun Baik,Seung Hyun Han,Seung Hyun Han,Kari Alitalo,Gou Young Koh +9 more
TL;DR: Results indicate that VEGF-C, -D, and -A derived from the CD11b+/Gr-1+ macrophages and local inflamed tissues play a critical role in promoting antigen clearance and inflammation resolution.