K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling
Tuomas Tammela,Georgia Zarkada,Harri Nurmi,Lars Jakobsson,Krista Heinolainen,Denis Tvorogov,Wei Zheng,Claudio A. Franco,Aino Murtomäki,Evelyn Aranda,Naoyuki Miura,Seppo Ylä-Herttuala,Marcus Fruttiger,Taija Makinen,Taija Makinen,Anne Eichmann,Jeffrey W. Pollard,Holger Gerhardt,Holger Gerhardt,Kari Alitalo +19 more
TL;DR: Results indicate that macrophage-derived VEGF-C activates VEGFR-3 in tip cells to reinforce Notch signalling, which contributes to the phenotypic conversion of endothelial cells at fusion points of vessel sprouts.
Journal ArticleDOI
Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1.
Lyn M. Wise,Tanja Veikkola,Andrew A. Mercer,Loreen J. Savory,Stephen B. Fleming,Carol Caesar,Angela A. Vitali,Taija Makinen,Kari Alitalo,Steven A. Stacker +9 more
TL;DR: Results indicate that, from a functional viewpoint, ORFV2-VEGF is indeed a member of the VEGF family of molecules, but is unique, however, in that it utilizes only VEGFR-2 and neuropilin-1.
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Peripheral Blood Platelets Express VEGF-C and VEGF which Are Released during Platelet Activation
Ulla Wartiovaara,Petri Salven,Hanna K. A. Mikkola,Riitta Lassila,Jaakko Kaukonen,Vladimir Joukov,Arto Orpana,Ari Ristimäki,Markku Heikinheimo,Heikki Joensuu,Kari Alitalo,Aarno Palotie +11 more
TL;DR: VEGF-C and VEGF, released from activated platelets, may have a role in angiogenesis during wound healing, and possibly also in other pathological conditions, such as atherosclerosis, tumour growth, and metastasis formation.
Journal ArticleDOI
Ligand-induced Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) Heterodimerization with VEGFR-2 in Primary Lymphatic Endothelial Cells Regulates Tyrosine Phosphorylation Sites
Johan Dixelius,Taija Makinen,Maria Wirzenius,Marika J. Karkkainen,Christer Wernstedt,Kari Alitalo,Lena Claesson-Welsh +6 more
TL;DR: The data suggest that the carboxyl-terminal tail of VEGFR-3 provides important regulatory tyrosine phosphorylation sites with potential signal transduction capacity and that these sites are differentially used in ligand-induced homo- and heterodimeric receptor complexes.
Journal ArticleDOI
Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis
Yukiji Takeda,Sandra Costa,Estelle Delamarre,Carmen Roncal,Rodrigo Leite de Oliveira,Mario Leonardo Squadrito,Veronica Finisguerra,Sofie Deschoemaeker,Françoise Bruyère,Mathias Wenes,Alexander Hamm,Jens Serneels,Julie Magat,Tapan Bhattacharyya,Tapan Bhattacharyya,Andrey Anisimov,Bénédicte F. Jordan,Kari Alitalo,Patrick H. Maxwell,Bernard Gallez,Zhen W. Zhuang,Yoshihiko Saito,Michael Simons,Michele De Palma,Massimiliano Mazzone +24 more
TL;DR: Unraveling how PHD2 regulates arteriogenesis and artery homeostasis by controlling a specific differentiation state in macrophages is unraveled and new treatment options for ischaemic disorders are suggested.