Kari Alitalo

TL;DR: A second isoform and the genomic structures of mouse and human vascular endothelial growth factor B and the entirely different COOH-terminal domains in the two isoforms imply that some functional properties of the two proteins are distinct.

TL;DR: Advances during the past decade have dramatically increased the knowledge of the mechanisms of lymphangiogenesis, including the roles of transcription factors,ymphangiogenic growth factors and their receptors, and intercellular and intracellular signaling cascades.

TL;DR: The capacity of a single dose of VEGF‐C to induce therapeutic lymphangiogenesis in acquired lymphedema is confirmed, in addition to improving lymphatic function and vascularity, VEGf‐C can apparently reverse the abnormalities in tissue architecture that accompany chronic lymphatic insufficiency.

TL;DR: Overexpression of VEGF‐C in transfected MCF‐7 cells stimulated in vivo tumor growth in xenotransplanted mice without affecting estrogen responsiveness and induces normally poorly metastatic estrogen‐dependent MCf‐7 tumors to disseminate to local lymph nodes, suggesting that VEGf‐C has an important role in lymph node metastasis of breast cancer even at its hormone‐dependent early stage.

TL;DR: Estrogen and androgen induction of VEGF expression and promotion of new vessel formation may be an important paracrine mechanism by which these hormones contribute to the early phase of tumor growth of hormonal cancer.