K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
Tie1 controls angiopoietin function in vascular remodeling and inflammation
Emilia A. Korhonen,Anita Lampinen,Hemant Giri,Andrey Anisimov,Minah Kim,Breanna M. Allen,Shentong Fang,Gabriela D'Amico,Tuomas Sipilä,Marja Lohela,Tomas Strandin,Antti Vaheri,Seppo Ylä-Herttuala,Gou Young Koh,Donald M. McDonald,Kari Alitalo,Pipsa Saharinen +16 more
TL;DR: It is determined that both ANG1 and ANG2 binding to Tie2 increases Tie1-Tie2 interactions in a β1 integrin-dependent manner and that Tie1 regulates ANG-induced Tie2 trafficking in endothelial cells, which supports a model in which Tie1 directly interacts with Tie2 to promote ANG- induced vascular responses under noninflammatory conditions.
Journal Article
Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts.
TL;DR: It is shown that these transcripts encode two polypeptides, FLT4s (short) and FLT41 (long), which are proteolytically processed in transfected cells and leukemia cells and which have different carboxy terminal tails.
Journal ArticleDOI
VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts.
Ingrid Nilsson,Fuad Bahram,Xiujuan Li,Laura Gualandi,Sina Koch,Malin Jarvius,Ola Söderberg,Andrey Anisimov,Ivana Kholová,Bronislaw Pytowski,Megan E. Baldwin,Seppo Ylä-Herttuala,Kari Alitalo,Johan Kreuger,Lena Claesson-Welsh +14 more
TL;DR: In this paper, the authors used in situ proximity ligation to detect receptor complexes in intact endothelial cells and found that both VEGFA and VEGFC potently induce formation of VEGFR2/-3 heterodimers.
Journal Article
The mouse tie receptor tyrosine kinase gene: expression during embryonic angiogenesis.
TL;DR: The results suggest that the tie receptor tyrosine kinase is involved in angiogenesis and/or maintenance of endothelial cell functions.
Journal ArticleDOI
Activation of hypoxia-inducible factor-1 in bacillary angiomatosis: evidence for a role of hypoxia-inducible factor-1 in bacterial infections.
Volkhard A. J. Kempf,Maria Lebiedziejewski,Kari Alitalo,Joo-Hee Wälzlein,Urs Ehehalt,Jeannette Fiebig,Stephan Huber,Burkhardt Schütt,Christian Sander,Steffen Müller,Guntram A. Grassl,Amir S. Yazdi,Bernhard R. Brehm,Ingo B. Autenrieth +13 more
TL;DR: The data provide for the first time evidence that HIF-1 may play a role in bacterial infections, and reveal that a B henselae infection resulted in the activation of genes typical for the cellular response to hypoxia.