K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization.
Maurice S. Brozzo,Saša Bjelić,Kaisa Kisko,Thomas Schleier,Veli-Matti Leppänen,Kari Alitalo,Fritz K. Winkler,Kurt Ballmer-Hofer +7 more
TL;DR: The energetically unfavorable homotypic interactions in D4-7 may be required for re-orientation of receptor monomers, and this mechanism might prevent ligand-independent activation of VEGFR-2 to evade the deleterious consequences for blood and lymph vessel homeostasis arising from inappropriate receptor activation.
Journal ArticleDOI
In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis
Ines Martinez-Corral,David Olmeda,Rodrigo Diéguez-Hurtado,Tuomas Tammela,Kari Alitalo,Sagrario Ortega +5 more
TL;DR: The Vegfr3EGFPLuc mouse model, where an EGFP-luciferase fusion protein, expressed under the endogenous transcriptional control of the VegFr3 gene, allows the monitoring of physiological and pathological lymphangiogenesis in vivo, is presented, which is the first reporter mouse model for luminescence imaging of lymphang iogenesis.
Journal ArticleDOI
Developmental expression of pim kinases suggests functions also outside of the hematopoietic system.
TL;DR: A novel quail cDNA with strong homology to the pim family of proto-oncogenes is cloned, suggesting novel functions for Pim family kinases during embryonic development, in particular in epithelia and in the central nervous system.
Journal ArticleDOI
State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association
Michael Simons,Kari Alitalo,Brian H. Annex,Hellmut G. Augustin,Craig Beam,Bradford C. Berk,Tatiana V. Byzova,Peter Carmeliet,William M. Chilian,John P. Cooke,George E. Davis,Anne Eichmann,M. Luisa Iruela-Arispe,Eli Keshet,Albert J. Sinusas,Christiana Ruhrberg,Y. Joseph Woo,Stefanie Dimmeler +17 more
TL;DR: In vivo models are required to understand the complex cellular interactions that enable the generation of functionally active and hierarchical blood vessel networks capable of providing an appropriate blood supply and paracrine stimuli to organs.
Posted ContentDOI
Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 - implications for microvascular inflammation and hypercoagulopathy in COVID-19 patients
Liqun He,Maarja Andaloussi Mäe,Lars Muhl,Ying Sun,Riikka Pietila,Khayrun Nahar,Elisa Vazquez Liebanas,Malin Jonsson Fagerlund,Anders Oldner,Jianping Liu,Guillem Genové,Stefanos Liptidis,Giuseppe Mocci,Simon Stritt,Andrey Anisimov,Karthik Amudhala Hemanthakumar,Markus Rasenen,Olivier Mirabeau,Emil M. Hansson,Johan Björkegren,Michael Vanlandewijck,Taija Makinen,Xiao-Rong Peng,Thomas D. Arnold,Kari Alitalo,Lars Eriksson,Urban Lendahl,Christer Betsholtz,Christer Betsholtz +28 more
TL;DR: It is shown that endothelial cells do not express angiotensin-converting enzyme-2 (ACE2), the SARS-CoV-2 receptor, and pericytes and microvascular smooth muscle cells express ACE2 in an organotypic manner, suggesting thatpericytes limit endothelial pro-thrombotic responses.