K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
Papers
More filters
Journal ArticleDOI
The cellular response to induction of the p21 c-Ha-ras oncoprotein includes stimulation of jun gene expression.
TL;DR: It is demonstrated that the expression of ornithine decarboxylase (ODC) mRNA is enhanced approximately 4‐6 h after the induction of the p21c‐ Ha‐ras oncoprotein, while constitutively elevated ODC was characteristic for stably c‐Ha‐ras‐transformed cells.
Journal ArticleDOI
Expression of growth factors and growth factor receptors in capillary hemangioblastoma.
TL;DR: It is concluded that capillary hemangioblastomas express a variety of growth factor receptors and ligands, potentially involved in both autocrine and paracrine loops.
Journal ArticleDOI
Is Angiopoietin-2 Necessary for the Initiation of Tumor Angiogenesis?
TL;DR: The novel finding that the angiopoietin-2 (Ang-2) signaling molecule is up-regulated in a spotlike fashion in the endothelium of growing blood vessels in glioblastoma is reported, showing that complex orchestration is required in order for angiogenesis to proceed.
Journal ArticleDOI
Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis
Sonja Koopal,Johanna Furuhjelm,Annika Järviluoma,Sari Jäämaa,Pawan Pyakurel,Christel Pussinen,Maria Wirzenius,Peter Biberfeld,Kari Alitalo,Marikki Laiho,Päivi M. Ojala +10 more
TL;DR: It is found that antiproliferative checkpoints are activated upon KSHV infection of ECs, and in early-stage but not late-stage lesions of clinical Kaposi sarcoma specimens, some of the first results suggesting that DNA damage checkpoint response also functions as an anticancer barrier in virally induced cancers.
Journal ArticleDOI
Avian vegf-c : cloning, embryonic expression pattern and stimulation of the differentiation of vegfr2-expressing endothelial cell precursors
Anne Eichmann,Catherine Corbel,Thierry Jaffredo,Christiane Bréant,V. Joukov,V. Kumar,Kari Alitalo,N M Le Douarin +7 more
TL;DR: VEGF-C appears to act during two different developmental phases, one early in posterior mesodermal V EGFR2-positive endothelial cell precursors which are negative for VEGFR3 and one later in regions rich in lymphatic vessels at a time when endothelial cells express both VEG FR2 and VEGfr3.