Kari Alitalo

TL;DR: The significant upregulation of VEGF and Tie in AVMs may indicate some ongoing angiogenesis, possibly contributing to the slow growth and maintenance of the AVM, and could be of potential use in the therapeutic targeting of these lesions.

TL;DR: In this article, the authors show that vascular endothelial growth factor (VEGF) signaling insufficiency, which is caused by increased production of decoy receptors, may drive physiological aging across multiple organ systems, and suggest that modulating this pathway may result in increased mammalian life span and improved overall health.

TL;DR: In this article, the authors discuss the other pathways where progress is made for drug development, in particular the angiopoietin (Ang)-Tie receptor pathway, and reveal that Tie2 utilizes a unique signaling mechanism at endothelial cell-cell junctions.

TL;DR: The results indicate that despite the compensatory roles of other Akt isoforms, Akt1 is more critically required during lymphatic development.

TL;DR: In this article, the authors investigated how Apc-mutant cells gain a clonal advantage over wild-type counterparts to achieve fixation and identified Notum as a key mediator during the early stages of mutation fixation that can be targeted to restore wild type cell competitiveness and provide preventative strategies for people at a high risk of developing colorectal cancer.