K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development.
Eola Kukk,Athina Lymboussaki,Suvi Taira,Arja Kaipainen,Michael Jeltsch,Vladimir Joukov,Kari Alitalo +6 more
TL;DR: In this paper, the authors reported the cloning and characterization of mouse VEGF-C, which is produced as a disulfide-linked dimer of 415 amino acid residue polypeptides.
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Lymphangiogenesis and cancer metastasis.
Steven A. Stacker,Marc G. Achen,Marc G. Achen,Lotta Jussila,Lotta Jussila,Megan E. Baldwin,Megan E. Baldwin,Kari Alitalo,Kari Alitalo +8 more
TL;DR: In this paper, the authors reviewed recent experimental and clinico-pathological data indicating that growth factors that stimulate lymphangiogenesis in tumours are associated with an enhanced metastatic process.
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Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.
TL;DR: It is shown that the homogeneously staining regions of the COLO 320 HSR marker chromosome contain amplified c- myc, and it seems reasonable to suspect that amplification of c-myc may have contributed to tumorigenesis.
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Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma.
Nicolas Dupin,Cyril Fisher,Paul Kellam,Samuel Ariad,Micheline Tulliez,Nathalie Franck,E van Marck,Dominique Salmon,Isabelle Gorin,Escande Jp,R A Weiss,Kari Alitalo,Chris Boshoff +12 more
TL;DR: No staining for LNA-1 is seen in samples from multiple myeloma, prostate cancer, and angiosarcoma, supporting the absence of any etiological link between these diseases and HHV-8.
Journal ArticleDOI
VEGFs and receptors involved in angiogenesis versus lymphangiogenesis.
TL;DR: Mouse models of lymphoedema have established VEGF-C as a promising agent for pro-lymphangiogenic therapy and VEGFR-3 has also been shown to be important for angiogenesis, acting together with V EGF/VEGFR-2 and Dll4/Notch signalling to control angiogenic sprouting.