K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance.
Zoltán Wiener,Jenny Högström,Ville Hyvönen,Arja M. Band,Pauliina Kallio,Tanja Holopainen,Olli Dufva,Caj Haglund,Olli Kruuna,Guillermo Oliver,Yinon Ben-Neriah,Kari Alitalo +11 more
TL;DR: It is found that Prox1 deletion reduced the number of stem cells and cell proliferation and decreased intestinal tumor growth via induction of annexin A1 and reduction of the actin-binding protein filamin A, which has been implicated as a prognostic marker in CRC.
Journal ArticleDOI
VEGF receptor 1 stimulates stem-cell recruitment and new hope for angiogenesis therapies
Ulf Eriksson,Kari Alitalo +1 more
TL;DR: Efforts to control vessel growth have focused on vascular endothelial growth factor and its primary receptor VEGFR-2, but new data could shift that focus to other members of the VEGF family and the receptor V EGFR-1, particularly in inflammatory diseases.
Book ChapterDOI
Endostatin signaling and regulation of endothelial cell-matrix interactions.
TL;DR: Studies on the effects of endostatin on cultured endothelial cells suggest that the antimigratory and antiproliferative properties of this molecule are the major mechanisms underlying its antiangiogenic potential.
Journal ArticleDOI
The p36 substrate of tyrosine-specific protein kinases co-localizes with non-erythrocyte alpha-spectrin antigen, p230, in surface lamina of cultured fibroblasts.
TL;DR: Polyclonal antisera and monoclonal antibodies are used in indirect immunofluorescence microscopy to study the subcellular location of p36 and the p230, which is a subplasmalemmal polypeptide showing immunologic cross‐reactivity with erythrocyte alpha‐spectrin.
Journal ArticleDOI
Recessive primary congenital lymphoedema caused by a VEGFR3 mutation
Arash Ghalamkarpour,Wolfgang Holnthoner,Pipsa Saharinen,Laurence M. Boon,John B. Mulliken,Kari Alitalo,Miikka Vikkula +6 more
TL;DR: The first case of isolated primary congenital lymphoedema with recessive inheritance, caused by a homozygous mutation in VEGFR3 is presented and it is suggested that large scale screening of V EGFR3 in all primary lymphOedema patients is necessary.