K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Amplification of ornithine decarboxylase gene in response to polyamine deprivation in Chinese hamster ovary cells.
TL;DR: A new mutant strain that has greatly increased ornithine decarboxylase activity is isolated from an arginase-deficient polyamine-dependent Chinese hamster ovary cell line, which enables the cells to decar boxylate lysine into cadaverine (diaminopentane) that is further converted into N-(3-aminopropyl)cadaverines and N,N'-bis(3-amino-bis-cada
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Structural analysis of vascular endothelial growth factor receptor-2/ligand complexes by small-angle X-ray solution scattering
Kaisa Kisko,Maurice S. Brozzo,John Missimer,Thomas Schleier,Andreas Menzel,Veli-Matti Leppänen,Kari Alitalo,Thomas Walzthoeni,Ruedi Aebersold,Kurt Ballmer-Hofer +9 more
TL;DR: This work analyzed the structural changes in the extracellular receptor domain that were induced by ligand binding and that represent the initial step in transmembrane signaling, culminating in the activation of the intracellular receptor kinase domain.
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VEGF-B Promotes Endocardium-Derived Coronary Vessel Development and Cardiac Regeneration.
Markus Räsänen,Ibrahim Sultan,Jennifer Paech,Karthik Amudhala Hemanthakumar,Wei Yu,Liqun He,Liqun He,Juan Tang,Ying Sun,Ruslan Hlushchuk,Xiuzheng Huan,Emma Armstrong,Oleksiy-Zakhar Khoma,Eero Mervaala,Valentin Djonov,Christer Betsholtz,Bin Zhou,Riikka Kivelä,Kari Alitalo +18 more
TL;DR: The myocardial VEGF-B transgene promotes the formation of endocardium-derived coronary vessels during development, endothelial proliferation in subendocardial myocardium in adult mice, and structural and functional rescue of cardiac tissue after myocardIAL infarction.
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Enhanced expression of transforming growth factor beta during megakaryoblastic differentiation of K562 leukemia cells
TL;DR: Platelet alpha granules contain several growth factors such as the transforming growth factor beta (TGF-beta) that are released during blood clotting and are thought to participate in the repair of tissue injury; however, the site of synthesis of platelet TGF- beta has not been demonstrated.
Journal Article
VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development
Eola Kukk,Athina Lymboussaki,Suvi Taira,Arja Kaipainen,Michael Jeltsch,Vladimir Joukov,Kari Alitalo +6 more
TL;DR: The cloning and characterization of mouse VEGF-C is reported, which is produced as a disulfide-linked dimer of 415 amino acid residue polypeptides, sharing an 85% identity with the human VEGf-C amino acid sequence, suggesting one of the functions of VEGC-C may be in the regulation of angiogenesis of the lymphatic vasculature.