K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Patent
Tie, a novel endothelial cell receptor tyrosine kinase
TL;DR: In this article, the cloning, sequencing and expression of a novel receptor tyrosine kinase, termed tie, is described, and the tie precursor comprises 1138 amino acid residues, about 1117 residues of which comprise the mature tie.
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Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain
M. Guy Roukens,Josi Peterson-Maduro,Yvonne Padberg,Michael Jeltsch,Veli-Matti Leppänen,Frank L. Bos,Kari Alitalo,Stefan Schulte-Merker,Dörte Schulte +8 more
TL;DR: In this article, the functional role of different CCBE1 protein domains was analyzed in vivo and in vitro, and it was shown that deletion of the collagen domains has a much stronger effect than deletion of EGF domains.
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Increased erythroid potentiating activity/tissue inhibitor of metalloproteinases and jun/fos transcription factor complex characterize tumor promoter-induced megakaryoblastic differentiation of K562 leukemia cells.
Riitta Alitalo,Juha Partanen,Liisa Pertovaara,Erkki Hölttä,Lea Sistonen,Leif C. Andersson,Kari Alitalo +6 more
TL;DR: The induction of EPA/TIMP and several other genes specific for the differentiating K562 cells may be a consequence of the sustained activation of immediate early genes encoding transcription factors, such as jun and c-fos.
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Vascular Endothelial Growth Factor (VEGF)/VEGF-C Mosaic Molecules Reveal Specificity Determinants and Feature Novel Receptor Binding Patterns
TL;DR: The analyzed super-VEGFs show both angiogenic and lymphangiogenic effects in vivo, although weaker than the parental molecules, and the composition of the VEGFR-3 binding molecules and scanning mutagenesis revealed determinants of receptor binding and specificity.
Journal ArticleDOI
Vascular endothelial growth factor receptor-3 in hypoxia-induced vascular development
Ingrid Nilsson,Charlotte Rolny,Yan Wu,Bronislaw Pytowski,Daniel J. Hicklin,Kari Alitalo,Lena Claesson-Welsh,Stefan Wennström +7 more
TL;DR: It is shown that hypoxic conditions (1% O2) potently stimulated formation of an extensive vascular network during a discrete stage of mouse embryonal stem cell differentiation, and that hypoxia‐driven vascular development requires the activity of VEGF receptor‐3.