K
Kari Lynn Ohlsen
Researcher at Torrey Pines Institute for Molecular Studies
Publications - 6
Citations - 2426
Kari Lynn Ohlsen is an academic researcher from Torrey Pines Institute for Molecular Studies. The author has contributed to research in topics: Calcium in biology & Calcium. The author has an hindex of 4, co-authored 6 publications receiving 2320 citations.
Papers
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Journal ArticleDOI
STIM1, an essential and conserved component of store-operated Ca2+ channel function
Jack Roos,Paul J. Digregorio,Andriy V. Yeromin,Kari Lynn Ohlsen,Maria I. Lioudyno,Shenyuan L. Zhang,Olga Safrina,J. Ashot Kozak,Steven L. Wagner,Michael D. Cahalan,Gonul Velicelebi,Kenneth A. Stauderman +11 more
TL;DR: It is proposed that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels.
Journal ArticleDOI
Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE
Lars Bertram,Christoph Lange,Kristina Mullin,Michele Parkinson,Monica Hsiao,Meghan F. Hogan,Brit Maren Michaud Schjeide,Basavaraj Hooli,Jason DiVito,Iuliana Ionita,Hongyu Jiang,Nan M. Laird,T J Moscarillo,Kari Lynn Ohlsen,Kathryn J. Elliott,Xin Wang,Diane Hu-Lince,Marie Ryder,Amy Murphy,Steven L. Wagner,Deborah Blacker,K. David Becker,Rudolph E. Tanzi +22 more
TL;DR: This study provides compelling evidence for the existence of at least one previously undescribed AD gene that, like APOE-epsilon4, primarily acts as a modifier of onset age.
Journal ArticleDOI
Molecular basis of the CRAC channel.
Michael D. Cahalan,Shenyuan L. Zhang,Andriy V. Yeromin,Kari Lynn Ohlsen,Jack Roos,Kenneth A. Stauderman +5 more
TL;DR: RNA interference screens together with over-expression and site-directed mutagenesis have identified the triggering molecule (Stim) that links store depletion to CRAC channel-mediated Ca(2+) influx and the pore subunit (Orai) of theCRAC channel that allows highly selective entry of Ca( 2+) ions into cells.
Patent
Methods of modulating and identifying agents that modulate intracellular calcium
TL;DR: In this paper, methods for identifying agents that modulate intracellular calcium are presented, as well as methods of modulating calcium within cells and methods of identifying proteins involved in modulating intra-cell calcium.
Patent
Composition comprising a cell comprising a STIM1 protein and an agent that modulates intracellular calcium and methods of use
TL;DR: In this article, methods for identifying agents that modulate intracellular calcium are presented, as well as methods of modulating calcium within cells and methods of identifying proteins involved in modulating intra-cell calcium.