K
Karin Broennimann
Researcher at Weizmann Institute of Science
Publications - 4
Citations - 21
Karin Broennimann is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications receiving 9 citations.
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Recruitment of DNA Repair MRN Complex by Intrinsically Disordered Protein Domain Fused to Cas9 Improves Efficiency of CRISPR-Mediated Genome Editing
TL;DR: The chimeric Cas9 constructs were two times more efficient in homology-directed editing of endogenous loci in tissue culture cells and the strategy was highly efficient in restoring a genetic defect in a cell line, exemplifying the possible implementation of the strategy in gene therapy.
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The C-Terminus of the PSMA3 Proteasome Subunit Preferentially Traps Intrinsically Disordered Proteins for Degradation
Assaf Biran,Nadav Myers,Shirel Steinberger,Julia Adler,Marianna Riutin,Karin Broennimann,Nina Reuven,Yosef Shaul +7 more
TL;DR: A model whereby the PSMA3 C-terminal region traps a subset of IDPs to facilitate their proteasomal degradation is proposed, which has the unique features previously recognized as characteristic 20S proteasome substrates in vitro.
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SARS-CoV-2 Omicron Specific Mutations Affecting Infectivity, Fusogenicity, and Partial TMPRSS2-Independency
TL;DR: In this paper , the authors reported that the specific Omicron Spike F375 residue decreases infectivity, and its conversion to the Delta S375 sequence significantly increases OmicRON infectivity.
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Evidence for a Hepatitis B Virus Short RNA Fragment Directly Targeting the Cellular RRM2 Gene
TL;DR: Results validate the requirement of the R2 gene expression for HBV replication and investigate the R1 regulation by ERE, a small RNA fragment within the HBx ORF that is sufficient to induce R2 upregulation.