Karlijn J. Doorn

TL;DR: The regional changes in microglial phenotype andTLR2 expression in primed/reactive microglia in the SN and HC of iLBD cases indicate that TLR2 may play a prominent role in the microglian-mediated responses that could be important for PD progression.

TL;DR: It is shown that the genetic profile of microglia already differs between different brain regions when studied under control conditions, which implies that brain region-specific microglial gene expression profiles exist that may contribute to the region- specific differences in microglian responsivity during disease conditions, such as seen in, e.g., PD.

TL;DR: Understanding how microglia can be neuroprotective in one brain region, while promoting neurotoxicity in another, will improve the understanding of the role of microglian cells in neurodegeneration in general and of their role in PD pathology in particular.

TL;DR: It is hypothesized that, in contrast to the classically affected brain regions of AD and PD patients, within the AON rather than neuronal loss, the increased density in amoeboid microglial cells, possibly in combination with neurite pathology, may contribute to functional deficits.

TL;DR: Findings indicate that Kv4.2 is expressed in both neuronal and glial cells and its regulation may involve potassium channel interacting proteins, alterations in the subcellular localization of the channel, as well as phosphorylation-mediated posttranslational modifications.