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Karol J. Mysels

Bio: Karol J. Mysels is an academic researcher from University of Southern California. The author has contributed to research in topics: Micelle & Conductivity. The author has an hindex of 24, co-authored 51 publications receiving 3648 citations. Previous affiliations of Karol J. Mysels include University of Manchester & R. J. Reynolds Tobacco Company.


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19 Mar 2018
TL;DR: The literature has been scanned for numerical values from 1926 up to and including 1966 and over 800 values, hitherto available in graphical form or implied in experimental data, have been extracted from the publications and are included Close to 5,000 entries, based on 333 references, dealing with 720 compounds are tabulated in the main tables Whenever available, the temperature, any additives present, the method of determination and the literature source are given for each CMC value and an indication of the apparent quality of the preparation and method used are included as mentioned in this paper.
Abstract: : Critical micelle concentrations (CMC's) have been collected, organized and evaluated The literature has been scanned for numerical values from 1926 up to and including 1966 In addition, over 800 values, hitherto available in graphical form or implied in experimental data, have been extracted from the publications and are included Close to 5,000 entries, based on 333 references, dealing with 720 compounds are tabulated in the main tables Whenever available, the temperature, any additives present, the method of determination and the literature source are given for each CMC value and an indication of the apparent quality of the preparation and method used are included A shorter table gives selected values which are believed to be particularly reliable, including highly accurate ones Among these, concordant values from at least two independent laboratories are emphasized Included in the Introduction is a general discussion of the importance and significance of CMC values and of methods for their determination, as well as a summary of the procedures used in the collection, evaluation and presentation of these values in the present work Extensive indexes are provided (Author)

1,199 citations

Journal ArticleDOI
TL;DR: In this article, a modified equilibrium Wilhelmy method was used to obtain accurate and precise surface tension measurements of surfactant solutions above the c.m.c. This finding places a definite limit upon the validity of the approximation represented by the phase separation theory of micelle formation.

310 citations


Cited by
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TL;DR: Some mechanisms that provide a rationale for the resolution afforded by zone electrophoresis in many gels will be detailed; the theory of some new modifications of zone electophoresis that have been designed to take maximum advantage of these mechanisms will be developed.
Abstract: Although electrophoresis is one of the most effective methods for the separation of ionic components of a mixture, the resolving power of different electrophoretic methods is quite variable. To separate two component ions, it is necessary to permit migration to continue until one of the kinds of ions has traveled at least one thickness of the volumes that it initially occupied (the starting zone) further than the other. However, the sharpness, and therefore the resolution, of the zones occupied by each ion diminishes with time because of the spreading of the zones as a result of diffusion. Remarkable resolution has been achieved when advantage is taken of the frictional properties of gels to aid separation by seiving at the molecular level (see Smithies’). A new method, disc electrophoresis, t has been designed that takes advantage of the adjustability of the pore size of a synthetic gel and that automatically produces starting zones of the order of 10 microns thickness from initial volumes with thicknesses of the order of centimeters. High resolution is thus achieved in very brief runs. With this technique, over 20 serum proteins are routinely separated from a sample of whole human serum as small as one microliter in a 20-minute run (see FIGURE 1) . Direct analysis of even very dilute samples becomes routine because the various ions are automatically concentrated to fixed high values at the beginning of the run just prior to separation. Preliminary laboratory studies and theoretic considerations provide evidence of the applicability of this technique to a wide range of ionic species for both analytic and large-scale preparative purposes. Theory has also provided the basis for a simple application of disc electrophoresis to the simultaneous determination of both the free mobility and the aqueous diffusion constant of a protein. This report will detail some mechanisms that provide a rationale for the resolution afforded by zone electrophoresis in many gels; will develop the theory of some new modifications of zone electrophoresis that have been designed to take maximum advantage of these mechanisms; and will provide some examples of the results that disc electrophoresis has produced.

4,255 citations

Journal ArticleDOI
TL;DR: This review focuses on work that deals with the mechanisms of detergent action in membrane solubilization including properties of detergents model lipid systems and detergent-protein interactions; in addition a possible sequence of events when deterGents interact with biological membranes receives attention.

2,850 citations

Journal ArticleDOI
TL;DR: In this article, the association properties of poly(ethylene oxide)-block-poly(propyleneoxide)-blockpoly(methylene oxide) (PEO) copolymers in aqueous solutions, and the adsorption at interfaces are reviewed.

1,730 citations

Journal ArticleDOI
A. Sheludko1

1,263 citations

Journal ArticleDOI
TL;DR: In this paper, a new type of chromatography with micellar solutions of ionic surfactants was examined, and linear relationships were observed between current and migration velocities of water, micelle, and any solute.
Abstract: Fundamental characteristics of a new type of chromatography with micellar solutions of ionic surfactants were examined. Electrokinetic phenomena in open-tubular capillaries move two phases, aqueous and micellar, with different velocities and micellar solubilization operates as the distribution process of solutes. Sodium dodecyl sulfate (SDS) solutions and a 0.05 mm i.d. x 650 mm fused silica tube were employed and high dc voltages up to 25 kV were applied. Linear relationships were observed between current and migration velocities of water, micelle, and any solute, but not between applied voltages and the velocities. This discrepancy can be reasonably interpreted in terms of the temperature rise of the solution in the tube resulting from Joule heating. Optimum resolutions can be obtained when the capacity factor is about 2, because retention times are limited between those of an insolubilized solute or water and a totally solubilized solute or micelle. Observed dependence of capacity factors on current can also be explained by the temperature rise. Thermodynamic parameters in micellar solubilization were presented. 22 references, 10 figures, 4 tables.

1,129 citations