K
Karsten Ruscher
Researcher at Humboldt State University
Publications - 5
Citations - 1800
Karsten Ruscher is an academic researcher from Humboldt State University. The author has contributed to research in topics: Erythropoietin & Ischemia. The author has an hindex of 5, co-authored 5 publications receiving 1691 citations. Previous affiliations of Karsten Ruscher include Russian Academy of Sciences.
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Journal ArticleDOI
Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation.
Konstantin Prass,Christian Meisel,Conny Höflich,Johann S. Braun,E. Halle,Tilo Wolf,Karsten Ruscher,Ilya V. Victorov,Josef Priller,Ulrich Dirnagl,Hans-Dieter Volk,Andreas Meisel +11 more
TL;DR: It is suggested that a catecholamine-mediated defect in early lymphocyte activation is the key factor in the impaired antibacterial immune response after stroke.
Journal ArticleDOI
Erythropoietin Is a Paracrine Mediator of Ischemic Tolerance in the Brain: Evidence from an In Vitro Model
Karsten Ruscher,Dorette Freyer,Maria Karsch,Nikolai Isaev,Dirk Megow,Birgit Sawitzki,Josef Priller,Ulrich Dirnagl,Andreas Meisel +8 more
TL;DR: The results establish EPO as an important paracrine neuroprotective mediator of ischemic preconditioning and provide evidence for the following signaling cascade: HIF-1 is activated rapidly by hypoxia in astrocytes and EPO activates the neuronal EPO receptor and, subsequently, JAK-2 and thereby PI3K.
Journal ArticleDOI
Hypoxia-Induced Stroke Tolerance in the Mouse Is Mediated by Erythropoietin
Konstantin Prass,Anna Scharff,Karsten Ruscher,Diana Löwl,Claudia Muselmann,Ilya V. Victorov,Krisztian Kapinya,Ulrich Dirnagl,Andreas Meisel +8 more
TL;DR: Endogenously produced EPO is an essential mediator of ischemic preconditioning in hypoxia-ischemia intervals and significantly reduced the protective effect of hypoxic pretreatment by 40%.
Journal ArticleDOI
Induction of tolerance in rat cortical neurons: hypoxic preconditioning
Ulrike Bruer,Markus Weih,N. K. Isaev,Andreas Meisel,Karsten Ruscher,A. Bergk,George Trendelenburg,Frank Wiegand,Ilya V. Victorov,Ulrich Dirnagl +9 more
TL;DR: Hypoxic preconditioning is a robust neuronal phenomenon in vitro with a similar temporal pattern and selective cellular vulnerability as the ischemic tolerance phenomenon shown in vivo.
Journal ArticleDOI
Induction of hypoxia inducible factor 1 by oxygen glucose deprivation is attenuated by hypoxic preconditioning in rat cultured neurons
Karsten Ruscher,N. K. Isaev,George Trendelenburg,Markus Weih,Linda Iurato,Andreas Meisel,Ulrich Dirnagl +6 more
TL;DR: A rapid and transient increase of HIF-1 DNA binding activity is shown in a dose dependent manner in primary cortical neurons of rats exposed to oxygen glucose deprivation (OGD) for 30, 60, 90, or 120 min.